线粒体Ca2+摄取的调控。

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Elizabeth Murphy, Charles Steenbergen
{"title":"线粒体Ca2+摄取的调控。","authors":"Elizabeth Murphy,&nbsp;Charles Steenbergen","doi":"10.1146/annurev-physiol-031920-092419","DOIUrl":null,"url":null,"abstract":"<p><p>Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca<sup>2+</sup> is a key modulator of both ATP production and cell death. Although mitochondrial Ca<sup>2+</sup> uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca<sup>2+</sup> uptake and efflux have been identified. The identification of the mitochondrial Ca<sup>2+</sup> uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca<sup>2+</sup> is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"83 ","pages":"107-126"},"PeriodicalIF":15.7000,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-031920-092419","citationCount":"17","resultStr":"{\"title\":\"Regulation of Mitochondrial Ca<sup>2+</sup> Uptake.\",\"authors\":\"Elizabeth Murphy,&nbsp;Charles Steenbergen\",\"doi\":\"10.1146/annurev-physiol-031920-092419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca<sup>2+</sup> is a key modulator of both ATP production and cell death. Although mitochondrial Ca<sup>2+</sup> uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca<sup>2+</sup> uptake and efflux have been identified. The identification of the mitochondrial Ca<sup>2+</sup> uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca<sup>2+</sup> is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.</p>\",\"PeriodicalId\":8196,\"journal\":{\"name\":\"Annual review of physiology\",\"volume\":\"83 \",\"pages\":\"107-126\"},\"PeriodicalIF\":15.7000,\"publicationDate\":\"2021-02-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1146/annurev-physiol-031920-092419\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual review of physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-physiol-031920-092419\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-physiol-031920-092419","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 17

摘要

线粒体负责ATP的产生,但也被称为细胞死亡的调节剂,线粒体基质Ca2+是ATP产生和细胞死亡的关键调节剂。虽然线粒体Ca2+摄取和外排已经研究了50多年,但直到过去十年,才确定了负责线粒体Ca2+摄取和外排的蛋白质。线粒体Ca2+单转运体(MCU)的鉴定导致了MCU调节因子研究的爆炸式增长。这些调节因子的水平以组织和疾病特异性的方式变化,为线粒体Ca2+如何调节提供了新的见解。这篇综述的重点是负责线粒体运输的蛋白质,以及我们从小鼠研究中了解到的这些蛋白质的遗传改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulation of Mitochondrial Ca2+ Uptake.

Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca2+ is a key modulator of both ATP production and cell death. Although mitochondrial Ca2+ uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca2+ uptake and efflux have been identified. The identification of the mitochondrial Ca2+ uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca2+ is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信