脊髓刺激对心力衰竭患者自主神经系统功能的急性影响。

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of applied biomedicine Pub Date : 2021-09-01 DOI:10.32725/jab.2021.012

Jan Naar, Deborah Jaye, Petr Neuzil, Petr Doskar, Filip Malek, Bengt Linderoth, Goran Lind, Marcus Stahlberg

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引用次数: 2

摘要

目的:验证脊髓刺激(SCS)急性改善心力衰竭(HF)患者心率变异性(HRV)和压力感受器敏感性(BRS)的假设。方法:在四种不同的设置下给予SCS(15分钟):90%的最大耐受刺激幅度(MTA)靶向T1-T4脊髓节段(SCS90T1-4)， 60%的MTA (SCS60T1-4)， 90%的MTA颅骨(SCS90CR)和尾侧(SCS90CA)电极配置。连续记录HRV和BRS，并将刺激与关闭设备进行比较。结果:纳入15例HF患者。SCS90T1-4未改变正常心跳间隔的标准差(SDNN, p = 0.90)、BRS (p = 0.55)及其他HRV参数。结论:60-90% MTA靶向上胸脊髓节段的急性SCS不能改善未选择的心力衰竭患者的自主神经平衡或压力感受器敏感性，但可能改善低SDNN患者的HRV。

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Acute effect of spinal cord stimulation on autonomic nervous system function in patients with heart failure.

Aims: To test the hypothesis that spinal cord stimulation (SCS) acutely improves heart rate variability (HRV) and baroreceptor sensitivity (BRS) in patients with heart failure (HF).

Methods: SCS (15 minutes) was delivered in four different settings: 90% of maximal tolerated stimulation amplitude (MTA) targeting the T1-T4 spinal cord segments (SCS90T1-4), 60% of MTA (SCS60T1-4), 90% of MTA with cranial (SCS90CR) and caudal (SCS90CA) electrode configuration. HRV and BRS were recorded continuously and stimulation was compared to device off.

Results: Fifteen HF patients were included. SCS90T1-4 did not change the standard deviation of intervals between normal beats (SDNN, p = 0.90), BRS (p = 0.55) or other HRV parameters. In patients with baseline SDNN <50 ms, SCS90T1-4 significantly increased SDNN (p = 0.004).

Conclusions: Acute SCS at 60-90% of MTA targeting upper thoracic spinal cord segments does not improve autonomic balance or baroreceptor sensitivity in unselected patients with heart failure but may improve HRV in patients with low SDNN.

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来源期刊

Journal of applied biomedicine PHARMACOLOGY & PHARMACY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.