匈牙利人群中常见食物和呼吸道过敏原的分子致敏模式

IF 2.3 3区 生物学 Q3 BIOCHEMICAL RESEARCH METHODS
Erzsébet Pintér , Mária Kun , Judit Konderák , Gabriella Páll , Lajos A. Réthy
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引用次数: 0

摘要

最近发展的基于免疫球蛋白e (IgE)的分子过敏诊断提供了在分子水平上识别致敏成分或成分的能力(成分解析诊断,CRD)。与经典的基于ige的过敏诊断相比,分子技术提供了更敏感和特异性的ige致敏模式。某些致敏模式是大地理区域的特征。只有很少的数据可获得的分子IgE致敏模式在东欧和中欧。本研究旨在提供该地区的进一步数据。方法回顾性分析2019年1月至12月在匈牙利进行的1288名受试者(平均年龄:27岁±18岁,男女比例0.56)血清中3993份匿名免疫帽分子IgE测量(CRD)数据,以获得致敏性(IgE >0.35 KU/l)分子过敏原的局部分布模式。结果CRD阳性病例占24.3%。其中,成人中最常见的吸入性过敏原是amb1(18%)和Art v1(8%), 18岁以下受试者中最常见的是Der p2(3%)和Der p1(3%)和amb1(4%)。同样的食物过敏原在成人中是gald2(21%)、bod1 4(17%)、bod1 5(11%),在儿童中是gald2(38%)、gald1(28%)、bod1 4(21%)、bod1 5(13%)和bod1 8(7%)。crd阳性病例中单敏感的比例为37.5%。结论我们的研究结果提供了匈牙利地区特异性致敏模式和分子过敏原传播。在过敏病例中相对较高的多致敏度强调了未来早期诊断和预防措施的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular sensitization patterns of common food-and respiratory allergens in the Hungarian population

Background

Recently developed Immunoglobulin-E (IgE) based molecular allergy diagnostics provide the ability of identifying allergenic components or ingredients at the molecular level (component-resolved-diagnosis, CRD). Compared to the classical IgE-based allergy diagnostics, molecular technology is providing more sensitive and specific IgE-sensitization patterns. Certain sensitization patterns are characteristic of large geographic regions. There are only few data available on the molecular IgE sensitization patterns in East-Central Europe. This study aims to present further data from this region.

Methods

Data of 3993 stored, anonymized molecular ImmunoCap IgE measurements (CRD), performed in Hungary between January-December 2019 from sera of 1288 subjects (mean age: 27 years ±18 years, male/female ratio 0.56) were analyzed retrospectively, in order to get a local distributional pattern of the sensitizing (IgE >0.35 KU/l) molecular allergens.

Results

The proportion of CRD positive cases was 24.3%. Amongst them, the most prevalent inhalative allergens were Amb a 1 (18%) Art v 1 (8%) in adults and Der p 2 (3%) and Der p 1 (3%) and Amb a 1 (4%) in subjects below 18 years of age. The same for food allergens were Gal d 2 (21%), Bos d 4 (17%), Bos d 5 (11%) in adults and Gal d 2 (38%), Gal d 1 (28%), Bos d 4 (21%), Bos d 5 (13%) and Bos d 8 (7%) in children. The ratio of mono-sensitivities among CRD-positive cases was 37.5%.

Conclusion

Our results provide region-specific patterns of sensitization and molecular allergen spreading for Hungary. The relatively higher abundance of polysensitization's among allergic cases underlines the need for early diagnostic -and preventive measures in the future.

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来源期刊
Molecular and Cellular Probes
Molecular and Cellular Probes 生物-生化研究方法
CiteScore
6.80
自引率
0.00%
发文量
52
审稿时长
16 days
期刊介绍: MCP - Advancing biology through–omics and bioinformatic technologies wants to capture outcomes from the current revolution in molecular technologies and sciences. The journal has broadened its scope and embraces any high quality research papers, reviews and opinions in areas including, but not limited to, molecular biology, cell biology, biochemistry, immunology, physiology, epidemiology, ecology, virology, microbiology, parasitology, genetics, evolutionary biology, genomics (including metagenomics), bioinformatics, proteomics, metabolomics, glycomics, and lipidomics. Submissions with a technology-driven focus on understanding normal biological or disease processes as well as conceptual advances and paradigm shifts are particularly encouraged. The Editors welcome fundamental or applied research areas; pre-submission enquiries about advanced draft manuscripts are welcomed. Top quality research and manuscripts will be fast-tracked.
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