囊性纤维化相关糖尿病:患病率、筛查和诊断

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM
Swapnil Khare , Marisa Desimone , Nader Kasim , Christine L. Chan
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引用次数: 15

摘要

囊性纤维化相关性糖尿病(CFRD)是囊性纤维化(CF)患者最常见的合并症。CFRD的患病率随着年龄的增长而增加,严重突变的患病率更高。与CFRD相关的其他危险因素有女性、胰腺功能不全、肝脏疾病、需要胃造口管饲、支气管肺曲菌病史和肺功能不良。CFRD与较差的临床结果和较高的死亡率有关。早期诊断和治疗已被证明可以改善临床结果。建议从10岁开始每年进行一次口服葡萄糖耐量试验(OGTT)筛查CFRD。CFRD的诊断是根据基线健康期间的标准美国糖尿病协会(ADA)标准做出的。CF患者在急性疾病、肠内喂养和移植后也可被诊断为CFRD。在这篇综述中,我们将讨论CFRD的流行病学,并概述目前CFRD筛查和诊断测试的优点和缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cystic fibrosis-related diabetes: Prevalence, screening, and diagnosis

Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in patients with cystic fibrosis (CF). Prevalence of CFRD increases with age and is greater with severe mutations. Other risk factors associated with CFRD are female sex, pancreatic insufficiency, liver disease, need for gastrostomy tube feedings, history of bronchopulmonary aspergillosis, and poor pulmonary function. CFRD is related to worse clinical outcomes and increased mortality. Early diagnosis and treatment have been shown to improve clinical outcomes. Screening for CFRD is recommended with an annual oral glucose tolerance test (OGTT) starting at age 10 years. Diagnosis of CFRD is made by standard American Diabetes Association (ADA) criteria during baseline health. CFRD can also be diagnosed in individuals with CF during acute illness, while on enteral feeds, and after transplant. In this review we will discuss the epidemiology of CFRD and provide an overview of the advantages and pitfalls of current screening and diagnostic tests for CFRD.

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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
24
审稿时长
16 weeks
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