转移性脑肿瘤患者的基线虚弱程度和年龄与术后效果的关系。

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY
Journal of neurosurgical sciences Pub Date : 2024-10-01 Epub Date: 2022-11-07 DOI:10.23736/S0390-5616.22.05865-9
Christine J Colasacco, Joanna Abouezzi, Sophia Arbuiso, Derek B Asserson, Syed F Kazim, Kyril L Cole, Alis J Dicpinigaitis, Jose Dominguez, Rohini G McKEE, Meic H Schmidt, William T Couldwell, Christian A Bowers
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引用次数: 0

摘要

背景:基线虚弱状态与实际年龄对转移性脑肿瘤患者手术结果的影响在很大程度上仍是未知数。本研究旨在利用大型国家数据库评估这种关系,以便进行术前风险分层:查询国家外科质量改进计划数据库,提取2015年至2019年期间接受手术的转移性脑肿瘤患者数据(n=5943)。研究人员进行了单变量和多变量分析,以评估年龄和改良虚弱指数-5(mFI-5)对死亡率、主要并发症、非计划再入院和再手术、延长住院时间(eLOS)和非居家出院的影响:单变量和多变量分析表明,虚弱状态对 30 天死亡率、主要并发症、eLOS 和非居家出院有显著的预测作用。虽然年龄的增加也是预测 eLOS 和非居家出院的一个重要因素,但与虚弱状态相比,其效应大小较小:本研究基于一项大型全国性登记数据的分析,结果表明,与年龄相比,体弱是预测转移性脑肿瘤患者术后结果的更优指标。未来的前瞻性研究,即随机对照试验,将有助于证实这项回顾性研究的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of baseline frailty and age with postoperative outcomes in metastatic brain tumor patients.

Background: The impact of baseline frailty status versus that of chronological age on surgical outcomes of metastatic brain tumor patients remains largely unknown. The present study aimed to evaluate this relationship for preoperative risk stratification using a large national database.

Methods: The National Surgical Quality Improvement Program database was queried to extract data of metastatic brain tumor patients who underwent surgery between 2015 and 2019 (N.=5943). Univariate and multivariate analyses were performed to assess the effect of age and modified Frailty Index-5 on mortality, major complications, unplanned readmission and reoperation, extended length of stay (eLOS), and non-home discharge.

Results: Both univariate and multivariate analyses demonstrated that frailty status was significantly predictive of 30-day mortality, major complications, eLOS, and non-home discharge. Although increasing age was also a significant predictor of eLOS and discharge to non-home destination, effect sizes were smaller compared with frailty.

Conclusions: The present study, based on analysis of data from a large national registry, shows that frailty, when compared with age, is a superior predictor of postoperative outcomes in metastatic brain tumor patients. A future prospective study, namely a randomized controlled trial, would be beneficial in helping to corroborate the findings of this retrospective study.

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来源期刊
Journal of neurosurgical sciences
Journal of neurosurgical sciences CLINICAL NEUROLOGY-SURGERY
CiteScore
3.00
自引率
5.30%
发文量
202
审稿时长
>12 weeks
期刊介绍: The Journal of Neurosurgical Sciences publishes scientific papers on neurosurgery and related subjects (electroencephalography, neurophysiology, neurochemistry, neuropathology, stereotaxy, neuroanatomy, neuroradiology, etc.). Manuscripts may be submitted in the form of ditorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.
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