用非对比自旋标记磁共振成像检测健康人脑脊液内流出量与年龄有关的下降。

IF 2.5 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Magnetic Resonance in Medical Sciences Pub Date : 2024-01-01 Epub Date: 2022-12-17 DOI:10.2463/mrms.mp.2022-0117
Vadim Malis, Won C Bae, Asako Yamamoto, Linda K McEvoy, Marin A McDonald, Mitsue Miyazaki
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引用次数: 0

摘要

目的:脑脊液(CSF)的清除对清除脑部毒素非常重要,对神经退行性疾病也有影响。人类脑脊液外流的成像评估一直很有限,主要依赖静脉或侵入性鞘瘤内注射造影剂。本研究的目的是引入一种新型自旋标记磁共振成像技术来检测和量化内源性标记 CSF 的移动,然后将其应用于评估不同年龄段正常人的 CSF 外流情况:这项研究是在知情同意的情况下,在一台临床 3-Tesla MRI 扫描仪上对 16 名年龄介于 19-71 岁之间的健康受试者进行的。我们的自旋标记磁共振成像技术在大脑半球上应用标记脉冲,并对标记 CSF 流入上矢状窦 (SSS) 的流出情况进行成像。我们实时获得三维图像,并对其进行分析,以确定脑脊液流出所涉及的脑膜不同区域的标记信号变化。此外,信号随时间的变化被拟合到信号曲线上,以确定定量流量指标。这些指标与受试者年龄相关,以确定衰老效应:结果:我们观察到标记的 CSF 信号从硬脑膜和副硬脑膜流出,最后排入 SSS。此外,我们还观察到在一些年轻受试者中可能存在另一种途径。此外,定量 CSF 流出指标显示,随着年龄的增长,CSF 流出指标会明显下降:我们展示了一种新型无创磁共振成像技术,该技术可识别两条固有的脑脊液清除途径,并观察到健康受试者的脑脊液流量指标随年龄增长而下降。我们的工作为更好地了解这些脑脊液清除途径在衰老过程中的关系提供了一个新的机会,这可能最终为神经退行性疾病与年龄相关的发病率提供启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-related Decline of Intrinsic Cerebrospinal Fluid Outflow in Healthy Humans Detected with Non-contrast Spin-labeling MR Imaging.

Purpose: Clearance of cerebrospinal fluid (CSF) is important for the removal of toxins from the brain, with implications for neurodegenerative diseases. Imaging evaluation of CSF outflow in humans has been limited, relying on venous or invasive intrathecal injections of contrast agents. The objective of this study was to introduce a novel spin-labeling MRI technique to detect and quantify the movement of endogenously tagged CSF, and then apply it to evaluate CSF outflow in normal humans of varying ages.

Methods: This study was performed on a clinical 3-Tesla MRI scanner in 16 healthy subjects with an age range of 19-71 years with informed consent. Our spin-labeling MRI technique applies a tag pulse on the brain hemisphere, and images the outflow of the tagged CSF into the superior sagittal sinus (SSS). We obtained 3D images in real time, which was analyzed to determine tagged-signal changes in different regions of the meninges involved in CSF outflow. Additionally, the signal changes over time were fit to a signal curve to determine quantitative flow metrics. These were correlated against subject age to determine aging effects.

Results: We observed the signal of the tagged CSF moving from the dura mater and parasagittal dura, and finally draining into the SSS. In addition, we observed a possibility of another pathway which is seen in some young subjects. Furthermore, quantitative CSF outflow metrics were shown to decrease significantly with age.

Conclusion: We demonstrate a novel non-invasive MRI technique identifying two intrinsic CSF clearance pathways, and observe an age-related decline of CSF flow metrics in healthy subjects. Our work provides a new opportunity to better understand the relationships of these CSF clearance pathways during the aging process, which may ultimately provide insight into the age-related prevalence of neurodegenerative diseases.

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来源期刊
Magnetic Resonance in Medical Sciences
Magnetic Resonance in Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
5.80
自引率
20.00%
发文量
71
审稿时长
>12 weeks
期刊介绍: Magnetic Resonance in Medical Sciences (MRMS or Magn Reson Med Sci) is an international journal pursuing the publication of original articles contributing to the progress of magnetic resonance in the field of biomedical sciences including technical developments and clinical applications. MRMS is an official journal of the Japanese Society for Magnetic Resonance in Medicine (JSMRM).
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