腹侧下托BNST通路的化学遗传学激活减少了上下文恐惧的表达。

IF 1.8 4区医学 Q4 NEUROSCIENCES

Learning & memory Pub Date : 2023-08-24 Print Date: 2023-08-01 DOI:10.1101/lm.053797.123

Leeza Kopaeva, Alexandrina Yakimov, Louise Urien, Elizabeth P Bauer

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引用次数: 0

摘要

在没有威胁的环境中无法减少恐惧是许多焦虑症的特征。根据FOS的表达，从腹侧下托（vSUB）到终纹床核（BNST）的通路在安全环境中比在厌恶环境中更活跃。在这里，我们使用化学遗传学技术，通过在BNST投射的vSUB神经元中表达Cre依赖性hM3D（Gq）受体，在上下文和提示的恐惧表达过程中特异性激活vSUB BNST通路。vSUB-BNST通路的激活减少了上下文，但没有提示恐惧的表达。这些数据表明，vSUB-BNST通路有助于对非可逆环境的行为反应。

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Chemogenetic activation of the ventral subiculum-BNST pathway reduces context fear expression.

An inability to reduce fear in nonthreatening environments characterizes many anxiety disorders. The pathway from the ventral subiculum (vSUB) to the bed nucleus of the stria terminalis (BNST) is more active in safe contexts than in aversive ones, as indexed by FOS expression. Here, we used chemogenetic techniques to specifically activate the vSUB-BNST pathway during both context and cued fear expression by expressing a Cre-dependent hM3D(Gq) receptor in BNST-projecting vSUB neurons. Activation of the vSUB-BNST pathway reduced context but not cued fear expression. These data suggest that the vSUB-BNST pathway contributes to behavioral responses to nonaversive contexts.

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来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.