[粘菌素的药理特性]。

Q3 Medicine

Klinicka mikrobiologie a infekcni lekarstvi Pub Date : 2022-06-01

Jitka Rychlíčková, Vendula Kubíčková

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引用次数: 0

摘要

粘菌素是一种窄谱脂肽抗菌剂，用于治疗多药耐药菌引起的院内感染，特别是危重患者和囊性纤维化患者。粘菌素是一种浓度-时间依赖性抗生素，具有高度可变的药代动力学，与目标人群的异质性和生物激活的必要性有关。粘菌素作为无活性前药粘菌酸钠给药。肾毒性和神经毒性是最常见的不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Pharmacological properties of colistin].

Colistin is a narrow-spectrum lipopeptide antimicrobial agent used to treat nosocomial infections caused by multidrug-resistant bacteria, especially in critically ill patients and those with cystic fibrosis. Colistin represents a concentration-time-dependent antibiotic with highly variable pharmacokinetics related to the heterogeneity of the target population and the necessity of bioactivation. Colistin is administered as the inactive prodrug colistimethate sodium. Nephrotoxicity and neurotoxicity are the most frequent adverse effects.

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来源期刊

Klinicka mikrobiologie a infekcni lekarstvi Medicine-Infectious Diseases

CiteScore

0.40

自引率

0.00%

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