{"title":"结核病患者治疗前随访损失的原因。","authors":"S Daka, Y Matsuoka, M Ota, S Hirao, A Phiri","doi":"10.5588/pha.22.0051","DOIUrl":null,"url":null,"abstract":"<p><strong>Setting: </strong>Five urban TB diagnostic centres in Lusaka, Zambia.</p><p><strong>Objective: </strong>To determine the proportion of bacteriologically confirmed pre-treatment lost to follow-up (LTFU) patients with TB found at the study settings in 2020.</p><p><strong>Design: </strong>This was a retrospective cohort study in which the TB laboratory and treatment registers at the study sites were cross-matched.</p><p><strong>Results: </strong>A total of 1,085 bacteriologically confirmed patients with TB were found in the laboratory TB registers at the study settings. Of these, 809 (74.6%) were males, whereas 8 (0.7%) were children, 1,005 (92.6%) were diagnosed using Xpert, 78 (7.2%) by microscopy. A total of 91 (8.4%, 95% CI 6.8-10.2) were determined to be pre-treatment LTFU. Those who had very low (14.0%, 95% CI 8.5-21.2) and low (11.8%, 95% CI 8.4-16.0) results on Xpert were respectively 3.1 (95% CI 1.6-6.0) and 2.6 (95% CI 1.4-4.8) times more likely to become pre-treatment LTFU than those who had medium (4.5%, 95% CI 2.5-7.4) results. The proportions of pre-treatment LTFU varied among the study sites from 0.7% to 16.1%.</p><p><strong>Conclusion: </strong>Health facilities should strive to account for every patient with TB, with particular attention to those who are bacteriologically confirmed.</p>","PeriodicalId":46239,"journal":{"name":"Public Health Action","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716822/pdf/i2220-8372-12-4-148.pdf","citationCount":"0","resultStr":"{\"title\":\"Causes of pre-treatment loss to follow-up in patients with TB.\",\"authors\":\"S Daka, Y Matsuoka, M Ota, S Hirao, A Phiri\",\"doi\":\"10.5588/pha.22.0051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Setting: </strong>Five urban TB diagnostic centres in Lusaka, Zambia.</p><p><strong>Objective: </strong>To determine the proportion of bacteriologically confirmed pre-treatment lost to follow-up (LTFU) patients with TB found at the study settings in 2020.</p><p><strong>Design: </strong>This was a retrospective cohort study in which the TB laboratory and treatment registers at the study sites were cross-matched.</p><p><strong>Results: </strong>A total of 1,085 bacteriologically confirmed patients with TB were found in the laboratory TB registers at the study settings. Of these, 809 (74.6%) were males, whereas 8 (0.7%) were children, 1,005 (92.6%) were diagnosed using Xpert, 78 (7.2%) by microscopy. A total of 91 (8.4%, 95% CI 6.8-10.2) were determined to be pre-treatment LTFU. Those who had very low (14.0%, 95% CI 8.5-21.2) and low (11.8%, 95% CI 8.4-16.0) results on Xpert were respectively 3.1 (95% CI 1.6-6.0) and 2.6 (95% CI 1.4-4.8) times more likely to become pre-treatment LTFU than those who had medium (4.5%, 95% CI 2.5-7.4) results. The proportions of pre-treatment LTFU varied among the study sites from 0.7% to 16.1%.</p><p><strong>Conclusion: </strong>Health facilities should strive to account for every patient with TB, with particular attention to those who are bacteriologically confirmed.</p>\",\"PeriodicalId\":46239,\"journal\":{\"name\":\"Public Health Action\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2022-12-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716822/pdf/i2220-8372-12-4-148.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Public Health Action\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5588/pha.22.0051\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Public Health Action","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5588/pha.22.0051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
摘要
环境:赞比亚卢萨卡的五个城市结核病诊断中心。目的:确定2020年在研究环境中发现的细菌学证实的治疗前失访(LTFU)结核病患者的比例。设计:这是一项回顾性队列研究，研究地点的结核病实验室和治疗登记是交叉匹配的。结果:在研究设置的实验室结核病登记中共发现1,085名细菌学确诊的结核病患者。其中，809例(74.6%)为男性，8例(0.7%)为儿童，1005例(92.6%)为Xpert诊断，78例(7.2%)为显微镜诊断。共有91例(8.4%，95% CI 6.8-10.2)被确定为治疗前LTFU。Xpert结果非常低(14.0%，95% CI 8.5-21.2)和低(11.8%，95% CI 8.4-16.0)的患者成为治疗前LTFU的可能性分别是中度(4.5%，95% CI 2.5-7.4)患者的3.1倍(95% CI 1.6-6.0)和2.6倍(95% CI 1.4-4.8)。处理前LTFU的比例在研究地点从0.7%到16.1%不等。结论:卫生机构应努力对每一位结核病患者作出解释，特别注意那些经细菌学证实的患者。
Causes of pre-treatment loss to follow-up in patients with TB.
Setting: Five urban TB diagnostic centres in Lusaka, Zambia.
Objective: To determine the proportion of bacteriologically confirmed pre-treatment lost to follow-up (LTFU) patients with TB found at the study settings in 2020.
Design: This was a retrospective cohort study in which the TB laboratory and treatment registers at the study sites were cross-matched.
Results: A total of 1,085 bacteriologically confirmed patients with TB were found in the laboratory TB registers at the study settings. Of these, 809 (74.6%) were males, whereas 8 (0.7%) were children, 1,005 (92.6%) were diagnosed using Xpert, 78 (7.2%) by microscopy. A total of 91 (8.4%, 95% CI 6.8-10.2) were determined to be pre-treatment LTFU. Those who had very low (14.0%, 95% CI 8.5-21.2) and low (11.8%, 95% CI 8.4-16.0) results on Xpert were respectively 3.1 (95% CI 1.6-6.0) and 2.6 (95% CI 1.4-4.8) times more likely to become pre-treatment LTFU than those who had medium (4.5%, 95% CI 2.5-7.4) results. The proportions of pre-treatment LTFU varied among the study sites from 0.7% to 16.1%.
Conclusion: Health facilities should strive to account for every patient with TB, with particular attention to those who are bacteriologically confirmed.
期刊介绍：
Launched on 1 May 2011, Public Health Action (PHA) is an official publication of the International Union Against Tuberculosis and Lung Disease (The Union). It is an open access, online journal available world-wide to physicians, health workers, researchers, professors, students and decision-makers, including public health centres, medical, university and pharmaceutical libraries, hospitals, clinics, foundations and institutions. PHA is a peer-reviewed scholarly journal that actively encourages, communicates and reports new knowledge, dialogue and controversy in health systems and services for people in vulnerable and resource-limited communities — all topics that reflect the mission of The Union, Health solutions for the poor.
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