Yaqing Zhou, Haijun Dan, Long Bai, Limei Jia, Baojin Lu, Guoqiang Gu, Wei Cui
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引用次数: 2
摘要
背景:高血压是人类健康的重大威胁，炎症与高血压有关。单核细胞与高密度脂蛋白胆固醇比值(MHR)是一种新的炎症指标。然而，MHR与高血压之间的关系尚不清楚。本研究调查了MHR与高血压的关系。方法:横断面研究，我们连续收集河北医科大学第二医院体检中心的数据(N = 6632)。数据包括患者的人口统计信息和临床信息，包括血压、血液生化测量和MHR。采用单因素和多因素logistic分析、平滑函数分析、阈值饱和效应分析和亚组分析等方法对MHR与高血压的关系进行检验。结果:结果显示MHR与高血压无调整正相关(优势比[OR] = 1.10, 95%可信区间[CI]: 1.08 ~ 1.12, P < 0.001)。在最小调整和完全调整模型中仍存在正相关(OR = 1.08, 95% CI: 1.06-1.10, P < 0.001;Or = 1.07, 95% ci: 1.05-1.10, p < 0.001)。广义加性模型的平滑函数分析显示，在所有MHR数据中，MHR与高血压之间存在连续的正线性关联(OR = 1.07, 95% CI: 1.05-1.10, P < 0.001)。亚组分析显示不同亚组间正相关的同质性。结论:在健康检查人群中，MHR与高血压之间存在持续的正线性关联。
Continuous Positive Linear Association between the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Hypertension: A Cross-Sectional Study.
Background: Hypertension poses a major threat to human health, and inflammation is associated with hypertension. The monocyte to high-density lipoprotein cholesterol ratio (MHR) represents a new inflammatory indicator. However, the relationship between the MHR and hypertension remains unclear. The present study investigated the association of MHR with hypertension.
Method: For this cross-sectional study, we continuously collected data from the Physical Examination Centre of the Second Hospital of Hebei Medical University (N = 6632). The data included patients' demographic information and clinical information including blood pressure, blood biochemical measurements, and MHR. The relationship between the MHR and hypertension was examined using different methods in univariate and multivariate logistic analysis, smooth function analysis, the threshold saturation effect analysis and subgroup analysis.
Results: The results showed that MHR was positively associated with hypertension without adjustment (odds ratio [OR] = 1.10, 95% confidence interval [CI]: 1.08-1.12, P < 0.001). The positive association still existed in minimally and fully adjusted models (OR = 1.08, 95% CI: 1.06-1.10, P < 0.001; OR = 1.07, 95% CI: 1.05-1.10, P < 0.001). Smooth function analysis of a generalized additive model revealed a continuous positive linear association between the MHR and hypertension throughout all MHR data (OR = 1.07, 95% CI: 1.05-1.10, P < 0.001). Subgroups analysis showed the homogeneity of the positive association among different subgroups.
Conclusions: A continuous positive linear association was found between the MHR and hypertension in a health examination population.
期刊介绍：
International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.
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