植物基因组及其他转座因子生命周期的表观遗传控制。

IF 8.7 1区生物学 Q1 GENETICS & HEREDITY

Annual review of genetics Pub Date : 2022-11-30 DOI:10.1146/annurev-genet-072920-015534

Peng Liu, Diego Cuerda-Gil, Saima Shahid, R Keith Slotkin

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引用次数: 9

摘要

在一个生物体的生命周期内，存在着另一个生命周期的自私的基因组居民，这被称为转座因子(te)。这些移动序列在基因组内侵入、复制、扩增和多样化，增加基因组的大小并产生新的突变。细胞保护它们的基因组，但不是永久性地破坏TE，而是使用染色质水平的抑制和表观遗传来沉默TE的活性。这种水平的沉默是短暂的和可逆的，导致宿主基因组内TE抑制和再激活之间的动态平衡。TE与宿主基因组的共存也可以导致TE的驯化，为宿主基因组的进化和功能服务。在这篇综述中，我们描述了TE的生命周期，重点是如何利用表观遗传调控来控制TE以促进宿主基因组的稳定和创新。

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The Epigenetic Control of the Transposable Element Life Cycle in Plant Genomes and Beyond.

Within the life cycle of a living organism, another life cycle exists for the selfish genome inhabitants, which are called transposable elements (TEs). These mobile sequences invade, duplicate, amplify, and diversify within a genome, increasing the genome's size and generating new mutations. Cells act to defend their genome, but rather than permanently destroying TEs, they use chromatin-level repression and epigenetic inheritance to silence TE activity. This level of silencing is ephemeral and reversible, leading to a dynamic equilibrium between TE suppression and reactivation within a host genome. The coexistence of the TE and host genome can also lead to the domestication of the TE to serve in host genome evolution and function. In this review, we describe the life cycle of a TE, with emphasis on how epigenetic regulation is harnessed to control TEs for host genome stability and innovation.

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来源期刊

Annual review of genetics 生物-遗传学

CiteScore

18.30

自引率

0.90%

发文量

期刊介绍： The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.