在基底神经节和相关脑干结构水平上,为接近和回避/逃避服务的通道分离了。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overton
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引用次数: 0

摘要

基底神经节的主要功能是根据环境事件和/或内部状态来指导我们的行为。这一功能依赖于以基底神经节主要输入结构为目标的传入,在纹状体水平输入行动选择的指令,或在丘脑下核水平输入行为中断的信号,多巴胺信号促进了行为的重新选择。许多实验研究了与大脑皮层输入有关的行为选择。然而,人们对基底节和脑干之间的解剖和功能联系知之甚少。在这篇综述中,我们描述了在接近和回避(包括逃离威胁)这两种动物基本的、相互排斥的行为选择中,脑干结构如何也投射到基底神经节的主要输入结构,即纹状体、丘脑下核和中脑多巴胺能神经元。我们重点研究了与接近和回避有关的三个描述特别清晰的位置,即上丘、脐旁核和下丘灰质周围核。我们研究了这些结构与基底神经节的关系,重点是它们向纹状体、多巴胺能神经元和丘脑下核的投射,并探讨了这些相互作用的功能性后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures.

The basal ganglia have the key function of directing our behavior in the context of events from our environment and/or our internal state. This function relies on afferents targeting the main input structures of the basal ganglia, entering bids for action selection at the level of the striatum or signals for behavioral interruption at the level of the subthalamic nucleus, with behavioral reselection facilitated by dopamine signaling. Numerous experiments have studied action selection in relation to inputs from the cerebral cortex. However, less is known about the anatomical and functional link between the basal ganglia and the brainstem. In this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal's repertoire in which the brainstem is strongly involved. We focus on three particularly well-described loci involved in approach and avoidance, namely the superior colliculus, the parabrachial nucleus and the periaqueductal grey nucleus. We consider what is known about how these structures are related to the basal ganglia, focusing on their projections toward the striatum, dopaminergic neurons and subthalamic nucleus, and explore the functional consequences of those interactions.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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