内皮细胞对运动诱导的流体剪切应力的线粒体和代谢适应。

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2022-07-01 DOI:10.1249/JES.0000000000000289

Soon-Gook Hong, Junchul Shin, Maitha Aldokhayyil, Michael David Brown, Joon-Young Park

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引用次数: 6

摘要

最近的研究极大地促进了我们对线粒体在内皮功能中的核心作用的理解。在这里，我们提出了一个假设，即单向层流(脉动)和扰动层流(振荡)可能在其生物能量、信号传导和生物合成功能的背景下不同地调节线粒体表型，为运动如何改善血管健康的亚细胞机制提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells.

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Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells.

Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis that unidirectional laminar (pulsatile) flow and disturbed laminar (oscillatory) flow may differentially modulate mitochondrial phenotypes in the context of their bioenergetic, signaling, and biosynthetic functions, providing novel insights into subcellular mechanisms underlying how exercise benefits the improvement of vascular health.

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.