腺苷信号传导作为心血管药理学的靶点。

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2023-08-01 DOI:10.1016/j.coph.2023.102393

Luca Antonioli , Matteo Fornai , Carolina Pellegrini , Pál Pacher , György Haskó

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引用次数: 0

摘要

越来越多的证据表明腺苷系统与心血管疾病的发生和发展有关，如高血压、心肌梗死、缺血、高血压、心力衰竭和动脉粥样硬化。在这方面，人们正集中精力研究腺苷在心血管疾病中的病理生理意义，腺苷作用于其膜受体A1、A2A、A2B和A3受体。这篇综述文章对腺苷在心血管疾病病理生理学中的作用的当前临床和临床前证据进行了综合全面的综述。特别关注的是目前的科学证据，即作用于腺苷途径的药理学配体是治疗心血管疾病的有用工具。

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Adenosine signaling as target in cardiovascular pharmacology

Increasing evidence demonstrated the relevance of adenosine system in the onset and development of cardiovascular diseases, such as hypertension, myocardial infarct, ischemia, hypertension, heart failure, and atherosclerosis. In this regard, intense research efforts are being focused on the characterization of the pathophysiological significance of adenosine, acting at its membrane receptors named A₁, A_2A, A_2B, and A₃ receptors, in cardiovascular diseases. The present review article provides an integrated and comprehensive overview about current clinical and pre-clinical evidence about the role of adenosine in the pathophysiology of cardiovascular diseases. Particular attention has been focused on current scientific evidence about the pharmacological ligands acting on adenosine pathway as useful tools to manage cardiovascular diseases.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.