fapi非恶性PET/CT表现:快速系统回顾

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Morten Bentestuen MD , Noor Al-Obaydi MD , Helle D. Zacho MD, PhD, DMSc
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引用次数: 11

摘要

成纤维细胞活化蛋白抑制剂(FAPI)在肿瘤学正电子发射断层扫描/计算机断层扫描(PET/CT)中是一种很有前途的示踪剂。大量研究表明,在几种类型的癌症中,FAPI PET/CT优于氟脱氧葡萄糖(FDG)PET/CT。然而,FAPI摄取的癌症特异性仍然研究不足,并且已经报道了几个假阳性FAPIPET/CT结果的病例。对PubMed、Embase和Web of Science进行了系统搜索,以查找2022年4月之前发表的报告非恶性FAPI PET/CT发现的研究。我们纳入了以英文发表的使用68Ga或18F放射性标记的FAPI示踪剂进行人体研究的原始同行评审文章。没有原始数据的论文和信息不足的研究被排除在外。未对准的发现以每个病变为基础,并根据所涉及的器官或组织类型进行分组。检索共发现1.178篇论文,其中108项研究符合条件。80项研究为病例报告(74%),其余28项为队列研究(26%)。共报告了2.372例FAPI狂热的非恶性发现,其中最常见的是动脉摄取,例如与斑块有关(n = 1178、49%)。FAPI摄取也经常与退行性和创伤性骨和关节病变有关(n = 147、6%)或关节炎(n = 92.4%)。对于器官,在炎症、感染、纤维化和IgG4相关疾病(n = 157、7%)。FAPI狂热的炎症/反应性淋巴结(n = 121,5%)和肺结核病变(n = 51,2%)已经被报道并且可能被证明是癌症分期的潜在陷阱。牙周炎(n = 76.3%)、痔疮(n = 47.2%)和瘢痕形成/伤口愈合(n = 35.2%)也表现为FAPI PET/CT上的局灶摄取。本综述概述了迄今为止报道的FAPI狂热的非恶性PET/CT发现。大量良性临床实体可能显示FAPI摄取,在解释癌症患者的FAPI PET/CT结果时应牢记这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
FAPI-avid nonmalignant PET/CT findings: An expedited systematic review

Fibroblast activation protein inhibitor (FAPI) is a promising tracer in oncologic positron emission tomography/computed tomography (PET/CT). Numerous studies have demonstrated the superior sensitivity of FAPI PET/CT over fluorodeoxyglucose (FDG) PET/CT in several types of cancer. However, the cancer specificity of FAPI uptake remains understudied, and several cases of false-positive FAPI PET/CT findings have been reported.

A systematic search of PubMed, Embase, and Web of Science was conducted for studies published prior to April 2022 reporting nonmalignant FAPI PET/CT findings. We included original peer-reviewed articles of studies in humans using FAPI tracers radiolabeled with 68Ga or 18F that were published in English. Papers without original data and studies with insufficient information were excluded. Nonmalignant findings were presented on a per-lesion basis and grouped according to the type of organ or tissue involved. The search identified a total of 1.178 papers, of which 108 studies were eligible. Eighty studies were case reports (74%), and the remaining 28 were cohort studies (26%). A total of 2.372 FAPI-avid nonmalignant findings were reported, with the most frequent being uptake in the arteries, e.g., related to plaques (n = 1178, 49%). FAPI uptake was also frequently related to degenerative and traumatic bone and joint lesions (n = 147, 6%) or arthritis (n = 92, 4%). For organs, diffuse or focal uptake was often seen in cases of inflammation, infection, fibrosis, and IgG4-related disease (n = 157, 7%). FAPI-avid inflammatory/reactive lymph nodes (n = 121, 5%) and tuberculosis lesions (n = 51, 2%) have been reported and could prove to be potential pitfalls in cancer staging. Periodontitis (n = 76, 3%), hemorrhoids (n = 47, 2%), and scarring/wound healing (n = 35, 2%) also presented as focal uptake on FAPI PET/CT. The present review provides an overview of the reported FAPI-avid nonmalignant PET/CT findings to date. A large number of benign clinical entities may show FAPI uptake and should be kept in mind when interpreting FAPI PET/CT findings in patients with cancer.

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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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