{"title":"表征小鼠颅面发育过程中Six2Cre的表达模式。","authors":"Meenakshi Umar, Chunmin Dong, Fenglei He","doi":"10.1002/dvg.23516","DOIUrl":null,"url":null,"abstract":"<p>Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of <i>Six2Cre</i> mice at multiple stages during craniofacial development. Our data revealed that <i>Six2Cre</i> lineage cells are predominantly present in frontal bone, mandible, and secondary palate. Using immunostaining method, we found that <i>Six2Cre</i> triggered reporter is co-expressed with Runx2. In summary, our data showed <i>Six2Cre</i> can be used to study gene function during palate development and osteogenesis in mouse models.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/8d/nihms-1909436.PMC10527692.pdf","citationCount":"0","resultStr":"{\"title\":\"Characterizing expression pattern of Six2Cre during mouse craniofacial development\",\"authors\":\"Meenakshi Umar, Chunmin Dong, Fenglei He\",\"doi\":\"10.1002/dvg.23516\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of <i>Six2Cre</i> mice at multiple stages during craniofacial development. Our data revealed that <i>Six2Cre</i> lineage cells are predominantly present in frontal bone, mandible, and secondary palate. Using immunostaining method, we found that <i>Six2Cre</i> triggered reporter is co-expressed with Runx2. In summary, our data showed <i>Six2Cre</i> can be used to study gene function during palate development and osteogenesis in mouse models.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/8d/nihms-1909436.PMC10527692.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/dvg.23516\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dvg.23516","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Characterizing expression pattern of Six2Cre during mouse craniofacial development
Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of Six2Cre mice at multiple stages during craniofacial development. Our data revealed that Six2Cre lineage cells are predominantly present in frontal bone, mandible, and secondary palate. Using immunostaining method, we found that Six2Cre triggered reporter is co-expressed with Runx2. In summary, our data showed Six2Cre can be used to study gene function during palate development and osteogenesis in mouse models.
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