Humera Fiaz, Abdul Rehman Khan, Shahid Abbas, Ahmed Bilal, Haq Nawaz Khan, Misbah Hussain, Fazli Rabbi Awan
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In total, 400 cardiometabolic patients and 226 healthy control human adults were enrolled from Faisalabad, Pakistan. Biochemical parameters (serum glucose, liver function test, renal function test and lipid profile) were analyzed by standard kit methods. Genetic analysis was done by ARMS-PCR assay. Data was analyzed in SPSS v20. Regression analysis revealed that GG and AG genotypes of rs2228570 A>G polymorphism significantly increased the risk of hypertension in cardiovascular patients by 5.29 and 5.94 times respectively (GG: OR=5.29, 95% CI=1.63-17.2, <b>p=0.005</b>; AG: OR=5.94, 95% CI=1.70-20.7, <b>p=0.005</b>). However, rs7975232 C>A polymorphism was not correlated with cardiometabolic conditions. 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引用次数: 0
摘要
除了与骨骼有关的作用外,维生素 D 还在免疫调节、高血压、糖尿病和心血管疾病中发挥作用。维生素 D 的代谢功能是与维生素 D 受体(VDR)结合后介导的。VDR 多态性会影响其生理功能。以前曾报道过几种 VDR 单核苷酸多态性(SNPs)。然而,迄今为止,尚未在巴基斯坦人群中调查 VDR 多态性对心血管和代谢疾病的影响。因此,本研究旨在评估 VDR 多态性(rs2228570 和 rs7975232)在心血管代谢紊乱病理生物学中的作用。研究人员从巴基斯坦费萨拉巴德(Faisalabad)共招募了 400 名心脏代谢疾病患者和 226 名健康对照组成人。生化指标(血清葡萄糖、肝功能检测、肾功能检测和血脂谱)采用标准试剂盒方法进行分析。基因分析采用 ARMS-PCR 检测法。数据用 SPSS v20 进行分析。回归分析表明,rs2228570 A>G 多态性的 GG 和 AG 基因型会显著增加心血管病人患高血压的风险,分别增加 5.29 倍和 5.94 倍(GG:OR=5.29,95% CI=1.63-17.2,p=0.005;AG:OR=5.94,95% CI=1.70-20.7,p=0.005)。然而,rs7975232 C>A 多态性与心脏代谢状况无关。总之,VDR SNP rs2228570的GG和AG基因型对心血管疾病患者的高血压有显著影响。
Association of vitamin D receptor polymorphisms with cardiometabolic conditions in Pakistani population.
Apart from bone related effects, vitamin D has roles in immune modulation, hypertension, diabetes and cardiovascular diseases. Metabolic functions of vitamin D are mediated after binding with vitamin D receptor (VDR). VDR polymorphisms affect its physiological functions. Several VDR single nucleotide polymorphisms (SNPs) were reported previously. However, VDR polymorphisms causing influence on cardiovascular and metabolic disorders have not been investigated in the Pakistani population so far. Therefore, the present study was conducted to evaluate the role of VDR polymorphisms (rs2228570 and rs7975232) in the pathobiology of cardiometabolic disorders. In total, 400 cardiometabolic patients and 226 healthy control human adults were enrolled from Faisalabad, Pakistan. Biochemical parameters (serum glucose, liver function test, renal function test and lipid profile) were analyzed by standard kit methods. Genetic analysis was done by ARMS-PCR assay. Data was analyzed in SPSS v20. Regression analysis revealed that GG and AG genotypes of rs2228570 A>G polymorphism significantly increased the risk of hypertension in cardiovascular patients by 5.29 and 5.94 times respectively (GG: OR=5.29, 95% CI=1.63-17.2, p=0.005; AG: OR=5.94, 95% CI=1.70-20.7, p=0.005). However, rs7975232 C>A polymorphism was not correlated with cardiometabolic conditions. In conclusion, GG and AG genotypes of VDR SNP rs2228570 significantly contribute to hypertension in cardiovascular disease patients.
期刊介绍:
Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds.
The editorial and advisory boards include many of the leading persons currently working in this area.
The journal is of particular interest to:
- Nutritionists
- Vitaminologists
- Biochemists
- Physicians
- Engineers of human and animal nutrition
- Food scientists