含有6-MSITC的山葵提取物对肌痛性脑脊髓炎/慢性疲劳综合征的临床疗效:一项开放标签试验。

IF 2.3 4区 医学 Q2 PSYCHIATRY
Takakazu Oka, Yu Yamada, Battuvshin Lkhagvasuren, Mutsuhiro Nakao, Ryota Nakajima, Masanobu Kanou, Ryuji Hiramatsu, Yo-Ichi Nabeshima
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The present study was conducted to investigate the effectiveness of wasabi extract containing 6-MSITC on ME/CFS in an open-label trial.</p><p><strong>Methods: </strong>Fifteen patients (3 males, 12 females, 20-58 years old) were orally administered wasabi extract (9.6 mg of 6-MSITC/day) for 12 weeks. The following parameters and test results were compared pre- and post-treatment: performance status (PS), self-rating questionnaires, pressure pain threshold (PPT) on the occiput, Trail Making test-A (TMT-A), and hemodynamic patterns determined by an active standing test.</p><p><strong>Results: </strong>After treatment with 6-MSITC, PS improved significantly (p = 0.001). 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引用次数: 2

摘要

背景:山葵(Eutrema japonicum)是日本常见的辛辣香料,在山葵根茎中发现的6-甲基亚磺酸基己基异硫氰酸酯(6-MSITC)已被证明具有抗炎和抗氧化作用,并改善神经炎症和记忆。因此,我们假设这些作用将有利于治疗肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)。本研究是在一项开放标签试验中研究含有6-MSITC的山葵提取物对ME/CFS的有效性。方法:15例患者(男3例,女12例,年龄20 ~ 58岁)口服山葵提取物(9.6 mg /d, 6-MSITC) 12周。比较治疗前后的以下参数和测试结果:运动状态(PS)、自评问卷、枕部压痛阈值(PPT)、Trail Making test- a (TMT-A)和主动站立试验确定的血流动力学模式。结果:6-MSITC治疗后,PS明显改善(p = 0.001)。虽然11项Chalder疲劳量表(CFS-11)和疲劳数值评定量表(NRS)的得分没有明显变化,但主观症状有明显改善,包括头痛频率(4.1 ~ 3.0次/周,p = 0.001)和肌痛(4.1 ~ 2.4次/周,p = 0.019), NRS脑雾评分(5.7 ~ 4.5次/周,p = 0.011),找词困难(4.8 ~ 3.7,p = 0.015),畏光(4.8 ~ 3.5,p = 0.008),心境状态剖面活力评分(46.9 ~ 50.0,p = 0.045)。右枕部PPT (17.3 ~ 21.3 kPa, p = 0.01)和TMT-A评分(53.0 ~ 38.1 s, p = 0.007)也发生了变化,分别表明疼痛敏感性降低,认知功能改善。站立试验确定的直立模式没有显示出显著的变化。未见严重不良反应。结论:本研究提示6-MSITC可改善ME/CFS患者的PS、疼痛、认知功能障碍等主观症状和心理活力。它还改善了这些患者的认知能力,增加了疼痛阈值。6-MSITC可能是一种有希望的治疗选择,特别是改善ME/CFS相关的认知功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial.

Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial.

Background: Wasabi (Eutrema japonicum) is a common pungent spice used in Japan. 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) found in the rhizome of wasabi has been shown to have anti-inflammatory and antioxidant effects, as well as improve neuroinflammation and memory. Therefore, we hypothesized that these effects would be beneficial for treating myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The present study was conducted to investigate the effectiveness of wasabi extract containing 6-MSITC on ME/CFS in an open-label trial.

Methods: Fifteen patients (3 males, 12 females, 20-58 years old) were orally administered wasabi extract (9.6 mg of 6-MSITC/day) for 12 weeks. The following parameters and test results were compared pre- and post-treatment: performance status (PS), self-rating questionnaires, pressure pain threshold (PPT) on the occiput, Trail Making test-A (TMT-A), and hemodynamic patterns determined by an active standing test.

Results: After treatment with 6-MSITC, PS improved significantly (p = 0.001). Although the scores on the 11-item Chalder Fatigue scale (CFS-11) and numerical rating scale (NRS) of fatigue did not show significant changes, subjective symptoms improved significantly, including headache frequency (4.1 to 3.0 times/week, p = 0.001) and myalgia (4.1 to 2.4 times/week, p = 0.019), NRS brain fog scores (5.7 to 4.5, p = 0.011), difficulty finding appropriate words (4.8 to 3.7, p = 0.015), photophobia (4.8 to 3.5, p = 0.008), and the Profile of Mood Status vigor score (46.9 to 50.0, p = 0.045). The PPT of the right occiput (17.3 to 21.3 kPa, p = 0.01) and TMT-A scores (53.0 to 38.1 s, p = 0.007) also changed, suggesting reduced pain sensitivity, and improved cognitive function, respectively. Orthostatic patterns determined by a standing test did not show remarkable changes. There were no serious adverse reactions.

Conclusion: This study suggests that 6-MSITC improves PS as well as subjective symptoms such as pain and cognitive dysfunction, and psychological vitality of patients with ME/CFS. It also improved cognitive performance and increased pain thresholds in these patients. 6-MSITC may be a promising therapeutic option especially for improving cognitive dysfunction associated with ME/CFS.

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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
23
审稿时长
18 weeks
期刊介绍: BioPsychoSocial Medicine is an open access, peer-reviewed online journal that encompasses all aspects of the interrelationships between the biological, psychological, social, and behavioral factors of health and illness. BioPsychoSocial Medicine is the official journal of the Japanese Society of Psychosomatic Medicine, and publishes research on psychosomatic disorders and diseases that are characterized by objective organic changes and/or functional changes that could be induced, progressed, aggravated, or exacerbated by psychological, social, and/or behavioral factors and their associated psychosomatic treatments.
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