植物混合物水提取物对大鼠模型的急性和亚慢性毒性研究(Bidens pilosa and Cymbopogon citratus airparts)。

IF 3.4 Q2 TOXICOLOGY
Yannick Carlos Tcheutchoua, Danielle Claude Bilanda, Yolande Sandrine Mengue Ngadena, Paul Désiré Djomeni Dzeufiet, Pascal Emmanuel Owona, Ronald Bidingha Á Goufani, Rodrigue Ngapout Fifen, Lohik Mbolang Nguegan, Michel Noubom, Théophile Dimo, Pierre Kamtchouing
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引用次数: 1

摘要

毛蔷薇(B. pilosa)和Cymbopogon citratus (C. citratus)是一种植物,可以单独使用,也可以组合使用,用于治疗心血管疾病等几种疾病。为了使它们的传统用途得到进一步的应用,对枇杷和柑橘的地上部分的混合物进行了毒理学研究。急性和亚慢性毒性研究是根据经合组织425和407指南进行的。在急性实验中,将毛缕草与柑橘草50:50(2000和5000mg /kg)的水提物分别给两性大鼠一次。在亚慢性实验中,大鼠每天给药1次,分别给药200、400和800 mg/kg的毛莲子和柑橘混合水提物,连续28天。在14天的观察中,毛缕草和柑橘混合水提物(2000和5000 mg/kg)未引起死亡,也未引起任何明显的毒性迹象。因此,该提取物的DL50大于5000mg /kg。每天服用28天,提取物对肾脏和肝脏功能的选定参数(肌酐、AST、ALT、尿素和尿酸)以及部分血细胞的数量没有显著影响。而双歧杆菌与柑桔混合水提液(200、400 mg/kg)对黄斑病的影响显著(p < 0.05;P < 0.001),与正常对照动物相比,雄性大鼠肌酐水平下降。在雌性动物中,与正常对照动物相比,毛蕊双生草和柑橘双生草混合水提物(200和400 mg/kg)导致总胆固醇水平显著(p < 0.05)升高。本研究表明,枸杞子与枸杞子混合水提物毒性低,对肝、肾、肺、脾无损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (<i>Bidens pilosa</i> and <i>Cymbopogon citratus</i> Aerial Parts) in Rat Model.

Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (<i>Bidens pilosa</i> and <i>Cymbopogon citratus</i> Aerial Parts) in Rat Model.

Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (<i>Bidens pilosa</i> and <i>Cymbopogon citratus</i> Aerial Parts) in Rat Model.

Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (Bidens pilosa and Cymbopogon citratus Aerial Parts) in Rat Model.

Bidens pilosa (B. pilosa) and Cymbopogon citratus (C. citratus) are plants used individually or in combination in the traditional treatment of several ailments such as cardiovascular disorders. In order to valorise their traditional use, a toxicological study was conducted on the aqueous extract of the mixture of aerial parts of B. pilosa and C. citratus. The acute and subchronic toxicity studies were conducted according to the OECD 425 and 407 guidelines. Regarding the acute study, the aqueous extract of the mixture of B. pilosa and C. citratus 50 : 50 (2000 and 5000 mg/kg) was administered once to rats of both sexes. In the subchronic study, the aqueous extract of the mixture of B. pilosa and C. citratus (200, 400 and 800 mg/kg) was administered once daily to rats for 28 days. The aqueous extract of the mixture of B. pilosa and C. citratus (2000 and 5000 mg/kg) did not cause death and did not induce any apparent sign of toxicity during the 14 days of observation. The DL50 of the extract is therefore greater than 5000 mg/kg. Taken daily for 28 days, the extract had no significant effect on selected parameters (creatinine, AST, ALT, urea, and uric acid) of renal and hepatic function, as well as on the number of some blood cells. However, the aqueous extract of the mixture of B. pilosa and C. citratus (200 and 400 mg/kg) caused a significant (p  <  0.05; p  <  0.001, respectively) decrease in creatinine levels in male rats as compared to normal control animals. In females, the aqueous extract of the mixture of B. pilosa and C. citratus (200 and 400 mg/kg) resulted in a significant (p  <  0.05) increase in total cholesterol levels as compared to normal control animals. The study showed that the aqueous extract of the mixture of B. pilosa and C. citratus has a low toxicity and does not cause any injury to the liver, kidney, lungs, or spleen.

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来源期刊
Journal of Toxicology
Journal of Toxicology TOXICOLOGY-
CiteScore
5.50
自引率
3.40%
发文量
0
审稿时长
10 weeks
期刊介绍: Journal of Toxicology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of toxicological sciences. The journal will consider articles looking at the structure, function, and mechanism of agents that are toxic to humans and/or animals, as well as toxicological medicine, risk assessment, safety evaluation, and environmental health.
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