昼夜节律与星形胶质细胞:好、坏、丑。

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-28 DOI:10.1146/annurev-neuro-100322-112249
Michael H Hastings, Marco Brancaccio, Maria F Gonzalez-Aponte, Erik D Herzog
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引用次数: 0

摘要

这篇综述探讨了昼夜节律计时与星形胶质细胞调节大脑功能之间的关系。虽然星形胶质细胞在许多时域调节神经元的活动,但它们的细胞自主昼夜节律钟在控制大脑功能的长期振荡方面发挥着特殊作用:维持睡眠状态以及睡眠和觉醒的昼夜顺序。这一点在中央昼夜节律起搏器--上丘脑核中最为明显,在这里,星形胶质细胞的分子钟足以驱动神经元活动和行为的每日周期。在阿尔茨海默病中,睡眠障碍伴随着认知能力的下降。在这种疾病的小鼠模型中,昼夜节律紊乱会加速星形胶质细胞的活化和其他脑部病变,这表明星形胶质细胞的日常功能可以保护神经元的稳态。在脑癌中,早晨治疗与延长生存期有关,胶质瘤的基因表达和药物敏感性也有日节律。因此,昼夜节律时间正迅速成为阐明健康和疾病中星形胶质细胞与神经元相互影响的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.

This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous circadian clocks exert a particular role in controlling longer-term oscillations of brain function: the maintenance of sleep states and the circadian ordering of sleep and wakefulness. This is most evident in the central circadian pacemaker, the suprachiasmatic nucleus, where the molecular clock of astrocytes suffices to drive daily cycles of neuronal activity and behavior. In Alzheimer's disease, sleep impairments accompany cognitive decline. In mouse models of the disease, circadian disturbances accelerate astroglial activation and other brain pathologies, suggesting that daily functions in astrocytes protect neuronal homeostasis. In brain cancer, treatment in the morning has been associated with prolonged survival, and gliomas have daily rhythms in gene expression and drug sensitivity. Thus, circadian time is fast becoming critical to elucidating reciprocal astrocytic-neuronal interactions in health and disease.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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