健康的社会决定因素与症状之间的表观基因组联系:范围综述》。

IF 1.9 4区 医学 Q2 NURSING
Biological research for nursing Pub Date : 2023-07-01 Epub Date: 2022-12-20 DOI:10.1177/10998004221147300
Mitali Ray, McKenzie K Wallace, Susan C Grayson, Meredith H Cummings, Jessica A Davis, Jewel Scott, Sarah M Belcher, Tara S Davis, Yvette P Conley
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引用次数: 0

摘要

健康的社会决定因素(SDoH)影响着健康和福祉。SDoH 与不良健康结果(包括症状的发生和严重程度)之间的联系可以通过个体对一种或多种 SDoH 的生理反应来解释。将 SDoH 与症状联系起来的生理反应的潜在机制之一是动态表观基因组。本文献综述旨在通过识别和总结通过表观基因组机制将 SDoH 与症状联系起来的研究,来研究症状的不同易感性。我们对 PubMed 进行了检索,以确定至少有一种 SDoH 是自变量或因变量、至少有一种症状受到调查、调查包括表观基因组测量的实证研究。在最初检索到的 484 篇文章中,经过彻底审查,有 41 篇符合资格。研究最多的症状是抑郁症状,其次是焦虑、认知功能、睡眠功能障碍和疼痛。研究最多的 SDoH 是1)压力,尤其是早期生活压力和文化适应压力;以及 2)创伤,主要是童年创伤。DNA 甲基化和端粒长度是研究最多的表观基因组测量指标。有四个基因(SLC6A4、BDNF、NR3C1、OXTR)在多项研究和不同的方法学方法中都有证据表明 SDoH 与症状有关。本综述支持采用表观基因组学方法来更好地了解 SDoH 与症状之间的联系,并提供了 SDoH 影响端粒长度和涉及神经递质信号转导、神经元存活、行为、炎症和应激反应的基因甲基化的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenomic Links Between Social Determinants of Health and Symptoms: A Scoping Review.

Social determinants of health (SDoH) impact health and wellness. The link between SDoH and adverse health outcomes, including symptom occurrence and severity, may be explained by an individual's physiologic response to one or more SDoH. One potential mechanism underlying this physiologic response linking SDoH and symptoms is the dynamic epigenome. The purpose of this scoping review of the literature was to examine differential susceptibility for symptoms by identifying and summarizing research linking SDoH and symptoms through epigenomic mechanisms. PubMed was searched to identify empirical research where at least one SDoH was an independent or dependent variable, at least one symptom was investigated, and the investigation included an epigenomic measure. Of the 484 articles initially retrieved, after thorough vetting, 41 articles met eligibility. The most studied symptom was depressive symptoms followed by anxiety, cognitive function, sleep dysfunction, and pain. The most frequently studied SDoH were: 1) stress, particularly early life stress and acculturative stress; and 2) trauma, predominantly childhood trauma. DNA methylation and telomere length were the most studied epigenomic measures. Four genes (SLC6A4, BDNF, NR3C1, OXTR) had evidence from multiple studies and across methodological approaches linking SDoH to symptoms. This review supports the inclusion of epigenomic approaches to better understand the link between SDoH and symptoms and provides evidence that SDoH impact telomere length and the methylation of genes involved in neurotransmitter signaling, neuronal survival, behavior, inflammation and stress response.

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来源期刊
CiteScore
5.10
自引率
4.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
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