{"title":"新生儿短暂性呼吸急促发展为新生儿肺动脉高压的危险因素:病例对照研究。","authors":"Gunlawadee Maneenil, Waricha Janjindamai, Supaporn Dissaneevate, Anucha Thatrimontrichai","doi":"10.2478/abm-2022-0034","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Transient tachypnea of the newborn (TTN) is the consequence of delayed resorption of lung fluid. When TTN develops, the infant may develop severe hypoxemia and progress to persistent pulmonary hypertension of the newborn (PPHN).</p><p><strong>Objectives: </strong>To examine factors associated with the development of PPHN in TTN infants.</p><p><strong>Methods: </strong>This retrospective study comprised 23 infants in whom a diagnosis of TTN with PPHN (TTN-PPHN) was confirmed and 59 infants with severe TTN without PPHN who required mechanical ventilation between 2009 and 2018 at Songklanagarind Hospital, Thailand. Logistic regression was used to assess factors associated with TTN and PPHN.</p><p><strong>Results: </strong>The factors identified by univariate analysis that were associated with development of PPHN were oxygen saturation (SpO<sub>2</sub>) <90% and respiratory rate (RR) ≥70 breaths/min at the time of admission, mean airway pressure (MAP) ≥8 cmH<sub>2</sub>O, oxygen index (OI) ≥10, partial pressure of oxygen (PaO<sub>2</sub>) ≤60, partial pressure of carbon dioxide (PCO<sub>2</sub>) ≥45 mmHg, and infants who did not receive positive pressure ventilation (PPV). In multivariate analyses, RR ≥70 breaths/min (adjusted odds ratio [aOR] 9.96, 95% confidence interval [CI] 2.1-47.29, <i>P</i> < 0.001) and OI ≥10 (aOR 29.22, 95% CI 4.46-191.23, <i>P</i> < 0.001) remained statistically significantly associated with PPHN.</p><p><strong>Conclusions: </strong>High RR and high OI were factors associated with PPHN in TTN infants.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"16 6","pages":"310-315"},"PeriodicalIF":0.4000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392143/pdf/","citationCount":"0","resultStr":"{\"title\":\"Risk factors of transient tachypnea of the newborn developing into pulmonary hypertension of the newborn: a case-control study.\",\"authors\":\"Gunlawadee Maneenil, Waricha Janjindamai, Supaporn Dissaneevate, Anucha Thatrimontrichai\",\"doi\":\"10.2478/abm-2022-0034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Transient tachypnea of the newborn (TTN) is the consequence of delayed resorption of lung fluid. When TTN develops, the infant may develop severe hypoxemia and progress to persistent pulmonary hypertension of the newborn (PPHN).</p><p><strong>Objectives: </strong>To examine factors associated with the development of PPHN in TTN infants.</p><p><strong>Methods: </strong>This retrospective study comprised 23 infants in whom a diagnosis of TTN with PPHN (TTN-PPHN) was confirmed and 59 infants with severe TTN without PPHN who required mechanical ventilation between 2009 and 2018 at Songklanagarind Hospital, Thailand. Logistic regression was used to assess factors associated with TTN and PPHN.</p><p><strong>Results: </strong>The factors identified by univariate analysis that were associated with development of PPHN were oxygen saturation (SpO<sub>2</sub>) <90% and respiratory rate (RR) ≥70 breaths/min at the time of admission, mean airway pressure (MAP) ≥8 cmH<sub>2</sub>O, oxygen index (OI) ≥10, partial pressure of oxygen (PaO<sub>2</sub>) ≤60, partial pressure of carbon dioxide (PCO<sub>2</sub>) ≥45 mmHg, and infants who did not receive positive pressure ventilation (PPV). In multivariate analyses, RR ≥70 breaths/min (adjusted odds ratio [aOR] 9.96, 95% confidence interval [CI] 2.1-47.29, <i>P</i> < 0.001) and OI ≥10 (aOR 29.22, 95% CI 4.46-191.23, <i>P</i> < 0.001) remained statistically significantly associated with PPHN.</p><p><strong>Conclusions: </strong>High RR and high OI were factors associated with PPHN in TTN infants.</p>\",\"PeriodicalId\":8501,\"journal\":{\"name\":\"Asian Biomedicine\",\"volume\":\"16 6\",\"pages\":\"310-315\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392143/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Biomedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2478/abm-2022-0034\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Biomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/abm-2022-0034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
背景:新生儿短暂性呼吸急促(TTN)是肺液吸收延迟的结果。当TTN发生时，婴儿可能发展为严重的低氧血症，并发展为新生儿持续性肺动脉高压(PPHN)。目的:探讨TTN患儿发生PPHN的相关因素。方法:本回顾性研究包括泰国Songklanagarind医院2009年至2018年期间确诊为TTN合并PPHN (TTN-PPHN)的23名婴儿和59名无PPHN且需要机械通气的严重TTN婴儿。采用Logistic回归评估与TTN和PPHN相关的因素。结果:单因素分析确定与PPHN发生相关的因素为血氧饱和度(SpO2) 2O、氧指数(OI)≥10、氧分压(PaO2)≤60、二氧化碳分压(PCO2)≥45 mmHg以及未接受正压通气(PPV)。在多变量分析中，RR≥70次/min(校正优势比[aOR] 9.96, 95%可信区间[CI] 2.1 ~ 47.29, P < 0.001)和OI≥10 (aOR 29.22, 95% CI 4.46 ~ 191.23, P < 0.001)与PPHN仍有统计学显著相关。结论:高RR和高OI是TTN患儿PPHN的相关因素。
Risk factors of transient tachypnea of the newborn developing into pulmonary hypertension of the newborn: a case-control study.
Background: Transient tachypnea of the newborn (TTN) is the consequence of delayed resorption of lung fluid. When TTN develops, the infant may develop severe hypoxemia and progress to persistent pulmonary hypertension of the newborn (PPHN).
Objectives: To examine factors associated with the development of PPHN in TTN infants.
Methods: This retrospective study comprised 23 infants in whom a diagnosis of TTN with PPHN (TTN-PPHN) was confirmed and 59 infants with severe TTN without PPHN who required mechanical ventilation between 2009 and 2018 at Songklanagarind Hospital, Thailand. Logistic regression was used to assess factors associated with TTN and PPHN.
Results: The factors identified by univariate analysis that were associated with development of PPHN were oxygen saturation (SpO2) <90% and respiratory rate (RR) ≥70 breaths/min at the time of admission, mean airway pressure (MAP) ≥8 cmH2O, oxygen index (OI) ≥10, partial pressure of oxygen (PaO2) ≤60, partial pressure of carbon dioxide (PCO2) ≥45 mmHg, and infants who did not receive positive pressure ventilation (PPV). In multivariate analyses, RR ≥70 breaths/min (adjusted odds ratio [aOR] 9.96, 95% confidence interval [CI] 2.1-47.29, P < 0.001) and OI ≥10 (aOR 29.22, 95% CI 4.46-191.23, P < 0.001) remained statistically significantly associated with PPHN.
Conclusions: High RR and high OI were factors associated with PPHN in TTN infants.
期刊介绍：
Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries
Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.
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