Jonatan Ottino-González, Renata B. Cupertino, Zhipeng Cao, Sage Hahn, Devarshi Pancholi, Matthew D. Albaugh, Ty Brumback, Fiona C. Baker, Sandra A. Brown, Duncan B. Clark, Massimiliano de Zambotti, David B. Goldston, Beatriz Luna, Bonnie J. Nagel, Kate B. Nooner, Kilian M. Pohl, Susan F. Tapert, Wesley K. Thompson, Terry L. Jernigan, Patricia Conrod, Scott Mackey, Hugh Garavan
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Here, we establish the robustness and value of SCN for identifying heavy alcohol users in three additional independent studies.</p>\n </section>\n \n <section>\n \n <h3> Design and Setting</h3>\n \n <p>Cross-sectional and longitudinal studies using data from the Pediatric Imaging, Neurocognition and Genetics (PING) study (<i>n</i> = 400, age range = 14–22 years), the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) (<i>n</i> = 272, age range = 17–22 years) and the Human Connectome Project (HCP) (<i>n</i> = 375, age range = 22–37 years).</p>\n </section>\n \n <section>\n \n <h3> Cases</h3>\n \n <p>Cases were defined based on heavy alcohol use patterns or former alcohol use disorder (AUD) diagnoses: 50, 68 and 61 cases were identified. Controls had none or low alcohol use or absence of AUD: 350, 204 and 314 controls were selected.</p>\n </section>\n \n <section>\n \n <h3> Measurements</h3>\n \n <p>Graph theory metrics of segregation and integration were used to summarize SCN.</p>\n </section>\n \n <section>\n \n <h3> Findings</h3>\n \n <p>Mirroring our prior findings, and across the three data sets, cases had a lower clustering coefficient [area under the curve (AUC) = −0.029, <i>P</i> = 0.002], lower modularity (AUC = −0.14, <i>P</i> = 0.004), lower average shortest path length (AUC = −0.078, <i>P</i> = 0.017) and higher global efficiency (AUC = 0.007, <i>P</i> = 0.010). Local efficiency differences were marginal (AUC = −0.017, <i>P</i> = 0.052). That is, cases exhibited lower network segregation and higher integration, suggesting that adjacent nodes (i.e. brain regions) were less similar in thickness whereas spatially distant nodes were more similar.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Structural covariance network (SCN) differences in the brain appear to constitute an early marker of heavy alcohol use in three new data sets and, more generally, demonstrate the utility of SCN-derived metrics to detect brain-related psychopathology.</p>\n </section>\n </div>","PeriodicalId":109,"journal":{"name":"Addiction","volume":"119 1","pages":"113-124"},"PeriodicalIF":5.2000,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.16330","citationCount":"0","resultStr":"{\"title\":\"Brain structural covariance network features are robust markers of early heavy alcohol use\",\"authors\":\"Jonatan Ottino-González, Renata B. 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Brain structural covariance network features are robust markers of early heavy alcohol use
Background and Aims
Recently, we demonstrated that a distinct pattern of structural covariance networks (SCN) from magnetic resonance imaging (MRI)-derived measurements of brain cortical thickness characterized young adults with alcohol use disorder (AUD) and predicted current and future problematic drinking in adolescents relative to controls. Here, we establish the robustness and value of SCN for identifying heavy alcohol users in three additional independent studies.
Design and Setting
Cross-sectional and longitudinal studies using data from the Pediatric Imaging, Neurocognition and Genetics (PING) study (n = 400, age range = 14–22 years), the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) (n = 272, age range = 17–22 years) and the Human Connectome Project (HCP) (n = 375, age range = 22–37 years).
Cases
Cases were defined based on heavy alcohol use patterns or former alcohol use disorder (AUD) diagnoses: 50, 68 and 61 cases were identified. Controls had none or low alcohol use or absence of AUD: 350, 204 and 314 controls were selected.
Measurements
Graph theory metrics of segregation and integration were used to summarize SCN.
Findings
Mirroring our prior findings, and across the three data sets, cases had a lower clustering coefficient [area under the curve (AUC) = −0.029, P = 0.002], lower modularity (AUC = −0.14, P = 0.004), lower average shortest path length (AUC = −0.078, P = 0.017) and higher global efficiency (AUC = 0.007, P = 0.010). Local efficiency differences were marginal (AUC = −0.017, P = 0.052). That is, cases exhibited lower network segregation and higher integration, suggesting that adjacent nodes (i.e. brain regions) were less similar in thickness whereas spatially distant nodes were more similar.
Conclusion
Structural covariance network (SCN) differences in the brain appear to constitute an early marker of heavy alcohol use in three new data sets and, more generally, demonstrate the utility of SCN-derived metrics to detect brain-related psychopathology.
期刊介绍：
Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines.
Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries.
Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.
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