有机体在再生医学中的应用。

IF 4 2区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

STEM CELLS Pub Date : 2023-12-14 DOI:10.1093/stmcls/sxad072

Yinghua Wu, Wenrui Ye, Yong Gao, Zhenjie Yi, Zhuohui Chen, Chunrun Qu, Jing Huang, Fangkun Liu, Zhixiong Liu

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引用次数: 1

摘要

再生医学主要依赖异源移植，但往往受到样本供应和伦理问题的阻碍。此外，患者还需要服用免疫抑制药物以防止不良副作用。干细胞衍生的三维类器官培养为移植和再生医学提供了新的选择。学者们已将类器官与组织工程技术结合起来，以提高可重复性、构成的准确性和通量，并通过基因校正实现更个性化的治疗。在此，我们回顾了器官组织在再生医学中的应用以及该领域目前面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Application of Organoids in Regenerative Medicine.

Regenerative medicine mainly relies on heterologous transplantation, often hindered by sample availability and ethical issues. Furthermore, patients are required to take immunosuppressive medications to prevent adverse side effects. Stem cell-derived 3D-organoid culture has provided new alternatives for transplantation and regenerative medicine. Scholars have combined organoids with tissue engineering technology to improve reproducibility, the accuracy of constitution and throughput, and genetic correction to achieve a more personalized therapy. Here, we review the available applications of organoids in regenerative medicine and the current challenges concerning this field.

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来源期刊

STEM CELLS 医学-生物工程与应用微生物

CiteScore

10.30

自引率

1.90%

发文量

104

审稿时长

3 months

期刊介绍： STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. STEM CELLS covers: Cancer Stem Cells, Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells, Regenerative Medicine, Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics, Tissue-Specific Stem Cells, Translational and Clinical Research.