{"title":"细胞类型特异性靶向的精确干预是未来癌症免疫疗法所必需的。","authors":"Yitong Cai, Anli Zhang, Changzheng Lu","doi":"10.1515/mr-2022-0037","DOIUrl":null,"url":null,"abstract":"Immune checkpoint blockade has represented a break-through for the treatment of human cancers, but only a minority of patients obtain clinical bene fi ts from this therapy. A critical issue is how to shape the “ cold ” tumor, characterized by desert or suppressive immunity, into a “ hot ” phenotype [1","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"2 6","pages":"553-554"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/e7/mr-2-6-mr-2022-0037.PMC10471107.pdf","citationCount":"1","resultStr":"{\"title\":\"Precision intervention of cell type-specific targeting is required for future cancer immunotherapy.\",\"authors\":\"Yitong Cai, Anli Zhang, Changzheng Lu\",\"doi\":\"10.1515/mr-2022-0037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Immune checkpoint blockade has represented a break-through for the treatment of human cancers, but only a minority of patients obtain clinical bene fi ts from this therapy. A critical issue is how to shape the “ cold ” tumor, characterized by desert or suppressive immunity, into a “ hot ” phenotype [1\",\"PeriodicalId\":74151,\"journal\":{\"name\":\"Medical review (Berlin, Germany)\",\"volume\":\"2 6\",\"pages\":\"553-554\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/e7/mr-2-6-mr-2022-0037.PMC10471107.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical review (Berlin, Germany)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/mr-2022-0037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical review (Berlin, Germany)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/mr-2022-0037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/12/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Precision intervention of cell type-specific targeting is required for future cancer immunotherapy.
Immune checkpoint blockade has represented a break-through for the treatment of human cancers, but only a minority of patients obtain clinical bene fi ts from this therapy. A critical issue is how to shape the “ cold ” tumor, characterized by desert or suppressive immunity, into a “ hot ” phenotype [1