Heloisa Vieira Prado, Enio Cássio Barreto Soares, Natália Cristina Ruy Carneiro, Ivanete Cláudia de Oliveira Vilar, Lucas Guimarães Abreu, Ana Cristina Borges-Oliveira
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OI is also known as brittle bone disease.</p><p><strong>Objective: </strong>This study aims to describe the prevalence of dental anomalies (except dentinogenesis imperfecta) in individuals with OI, and compare the prevalence of dental anomalies between individuals with and without OI and between individuals with different types of OI.</p><p><strong>Search methods: </strong>Searches in PubMed, Web of Science, Scopus, Ovid, and gray literature were performed in October 2022.</p><p><strong>Selection criteria: </strong>Observational studies (with or without a comparison group) that evaluated the prevalence of dental anomalies in individuals with OI. Data collection and analysis: Data items were extracted by two authors. Quality assessment employing the Joanna Briggs Institute checklists and meta-analyses was conducted. Results were provided in prevalence values and odds ratio (OR) / 95% confidence interval (CI). Strength of evidence was determined.</p><p><strong>Results: </strong>Eighteen studies were included. Most prevalent dental anomalies in individuals with OI included pulp obliteration (46.4%), dental impaction (33.5%), dental impaction of second molars (27%), and tooth agenesis (23.9%). Individuals with OI type III/IV had 20.16-fold greater chance of exhibiting tooth discoloration in comparison with individuals with OI type I (CI: 1.10-370.98). In comparison with the group without OI, the individuals with OI had 6.90-fold greater chance of exhibiting dental impaction (CI: 1.54-31.00). High methodological quality was found in 47% of the studies. Strength of evidence was low or very low.</p><p><strong>Conclusions: </strong>Pulp obliteration, dental impaction, and tooth agenesis were the most prevalent dental anomalies in the OI group. Individuals with OI were more likely to have dental impaction than individuals without OI. 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引用次数: 0
摘要
背景：成骨不全（OI）是一种罕见的遗传性疾病，主要由1型胶原产生相关基因的突变引起。OI也被称为脆性骨病。目的：本研究旨在描述OI患者牙齿异常（牙本质发育不全除外）的患病率，并比较有和无OI患者以及不同类型OI患者的牙齿异常患病率。搜索方法：在PubMed、Web of Science、Scopus、Ovid、，和灰色文献于2022年10月进行。选择标准：观察性研究（有或没有对照组），评估OI患者牙齿异常的患病率。数据收集和分析：数据项由两位作者提取。采用乔安娜·布里格斯研究所的检查表和荟萃分析进行质量评估。结果提供了患病率值和比值比（OR）/95%置信区间（CI）。证据的强度已经确定。结果：纳入18项研究。OI患者中最常见的牙齿异常包括牙髓闭塞症（46.4%）、牙齿嵌塞症（33.5%）、第二磨牙牙齿嵌塞病（27%）和牙齿发育不全症（23.9%）。与I型OI患者相比，III/IV型OI的患者出现牙齿变色的几率高20.16倍（CI:1.10-370.98），OI患者表现出牙齿嵌塞的几率高出6.90倍（CI:1.54-31.00）。47%的研究具有较高的方法学质量。证据的强度很低或很低。结论：牙髓闭塞、牙嵌塞和牙齿发育不全是OI组最常见的牙齿异常。患有OI的个体比没有OI的个人更有可能发生牙齿嵌塞。患有OI III/IV型（严重-中度）的个体比患有OI I型（轻度）的个体更有可能出现牙齿变色。
Dental anomalies in individuals with osteogenesis imperfecta: a systematic review and meta-analysis of prevalence and comparative studies.
Background: Osteogenesis imperfecta (OI) is a rare genetic disorder primarily caused by mutations in the genes involved in the production of type 1 collagen. OI is also known as brittle bone disease.
Objective: This study aims to describe the prevalence of dental anomalies (except dentinogenesis imperfecta) in individuals with OI, and compare the prevalence of dental anomalies between individuals with and without OI and between individuals with different types of OI.
Search methods: Searches in PubMed, Web of Science, Scopus, Ovid, and gray literature were performed in October 2022.
Selection criteria: Observational studies (with or without a comparison group) that evaluated the prevalence of dental anomalies in individuals with OI. Data collection and analysis: Data items were extracted by two authors. Quality assessment employing the Joanna Briggs Institute checklists and meta-analyses was conducted. Results were provided in prevalence values and odds ratio (OR) / 95% confidence interval (CI). Strength of evidence was determined.
Results: Eighteen studies were included. Most prevalent dental anomalies in individuals with OI included pulp obliteration (46.4%), dental impaction (33.5%), dental impaction of second molars (27%), and tooth agenesis (23.9%). Individuals with OI type III/IV had 20.16-fold greater chance of exhibiting tooth discoloration in comparison with individuals with OI type I (CI: 1.10-370.98). In comparison with the group without OI, the individuals with OI had 6.90-fold greater chance of exhibiting dental impaction (CI: 1.54-31.00). High methodological quality was found in 47% of the studies. Strength of evidence was low or very low.
Conclusions: Pulp obliteration, dental impaction, and tooth agenesis were the most prevalent dental anomalies in the OI group. Individuals with OI were more likely to have dental impaction than individuals without OI. Individuals with OI type III/IV (severe-moderate) are more likely to have tooth discoloration than individuals with OI type I (mild).
期刊介绍：
The Journal of Applied Oral Science is committed in publishing the scientific and technologic advances achieved by the dental community, according to the quality indicators and peer reviewed material, with the objective of assuring its acceptability at the local, regional, national and international levels. The primary goal of The Journal of Applied Oral Science is to publish the outcomes of original investigations as well as invited case reports and invited reviews in the field of Dentistry and related areas.
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