[在非洲提高使用可注射脊髓灰质炎疫苗的扩大免疫流动战略的效率]。

Martin Schlumberger
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引用次数: 0

摘要

导言:1980年,合作伙伴发起了一项流动简化扩大免疫规划(扩大免疫规划)战略,由流动小组在西非农村和城市人口进行免疫接种。该战略分两次提供扩大免疫方案疫苗:1)3-8个月大的儿童:白喉-破伤风-百日咳+强化脊髓灰质炎灭活疫苗;2) 9-15月龄儿童:白喉、破伤风、百日咳+强化灭活脊髓灰质炎疫苗、麻疹-黄热病。该战略与世卫组织-联合国儿童基金会扩大扩大免疫战略进行了比较,但结果从未在计划用口服脊髓灰质炎疫苗快速消灭脊髓灰质炎的背景下公布。方法:为了与标准的世卫组织-联合国儿童基金会扩大扩大免疫战略进行比较,在四届会议中使用口服脊髓灰质炎疫苗,1988年这两种战略产生的所有费用已在西非布基纳法索的两个相邻地区收集:世卫组织-联合国儿童基金会扩大扩大免疫战略的203,642名居民(Yako);109,483名居民采用移动简化扩大免疫战略(Gourci)。今年年底在这两个相邻地区进行了扩大免疫方案覆盖率调查,并计算了效率(每个充分免疫儿童的费用)。结果:在非洲,使用强化脊髓灰质炎灭活疫苗的简化流动扩大免疫战略的效率(每名完全免疫儿童12.71美元)比使用口服脊髓灰质炎疫苗的世卫组织-联合国儿童基金会扩展扩大免疫战略(每名完全免疫儿童29.67美元)高两倍,即使白喉白喉强化脊髓灰质炎灭活疫苗(每剂0.52美元)比白喉白喉和口服脊髓灰质炎疫苗(联合剂量0.14美元)贵。世卫组织-联合国儿童基金会扩大扩大免疫战略如果错过机会,覆盖面将增加一倍,而移动简化扩大免疫战略的覆盖面仅增加10%。世卫组织扩大扩大免疫战略未抓住的错失机会的主要原因是,卫生工作人员在接诊人群时,由于轻便摩托车上携带的用于运输疫苗的冷箱容量不足,未能交付所要求的疫苗。讨论:自1990年以来,在非洲使用口服脊髓灰质炎疫苗消灭脊髓灰质炎30年之后,在这项大规模脊髓灰质炎运动研究中没有增加费用,这些结果应该发表,以审查扩大免疫战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

[Increasing the efficiency of a mobile EPI strategy using injectable polio vaccine in Africa].

[Increasing the efficiency of a mobile EPI strategy using injectable polio vaccine in Africa].

[Increasing the efficiency of a mobile EPI strategy using injectable polio vaccine in Africa].

[Increasing the efficiency of a mobile EPI strategy using injectable polio vaccine in Africa].

Introduction: In 1980, partners initiated a mobile simplified EPI (Expanded programme on immunization) strategy for immunizing, with mobile teams, rural and urban populations in Western Africa. This strategy delivered EPI vaccines in two sessions: 1) 3-8 month-old children: BCG-Diphteria Tetanus Pertussis + reinforced killed Polio vaccine; 2) 9-15 month-old children: Diphteria Tetanus Pertussis + reinforced killed Polio vaccine, Measles-Yellow Fever. This strategy was compared to WHO-UNICEF extended EPI strategy, but results were never published in the context of a planned rapid polio eradication with oral polio vaccine.

Methods: For comparison with standard WHO-UNICEF extended EPI strategy, using oral polio vaccine in four sessions, all the costs generated by these two strategies in 1988 have been collected in two adjacent zones in Burkina Faso, Western Africa: 203,642 inhabitants for WHO-UNICEF extended EPI strategy (Yako); 109,483 inhabitants for mobile simplified EPI strategy (Gourci). An EPI coverage survey at the end of this year has been done in these two adjacent zones with efficiency (costs per fully immunized child) computed.

Results: In Africa, the simplified mobile EPI strategy using reinforced killed polio vaccine was found two times more efficient (12.71 US$ per fully immunized child) than WHO-UNICEF extended EPI strategy using oral polio vaccine (29.67 US$ per fully immunized child), even if DTP-reinforced killed polio vaccine (0.52 US$ per dose) was more expensive than DTP and oral polio vaccine (0.14 US$ for the combined dose). The missed opportunities uncaught up would have doubled coverage in the WHO-UNICEF extended EPI strategy, versus only a 10% increase with the mobile simplified EPI strategy. The main reason for uncaught up missed opportunities in WHO extended EPI strategy was the absence of requested vaccine delivered by a health agent when attending population at meeting point, due to insufficient cold box volume carried on his moped for transport of vaccine.

Discussion: After 30 years, since 1990, of poliomyelitis eradication in Africa using oral polio vaccine and with non-added costs in this study of polio mass campaigns, these results should be published to review EPI strategy.

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