年龄和临床生化指标对 SARS-CoV-2 感染临床严重程度的影响

IF 3.2 4区 医学 Q3 VIROLOGY
Intervirology Pub Date : 2023-01-01 Epub Date: 2023-06-01 DOI:10.1159/000530906
Shariq Ahmad Wani, Babar Gulzar, Mosin Saleem Khan, Sabhiya Majid, Irfan Ahmad Bhat
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引用次数: 0

摘要

导言:新型严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染的激增导致冠状病毒病-2019(COVID-19),使卫生系统不堪重负。为了帮助医护人员和政策制定者确定治疗的优先次序并减轻 COVID-19 给卫生系统造成的负担,我们设计了一项横断面研究,对来自印度克什米尔山谷的 236 名 SARS-CoV-2 感染者的临床严重程度和各种临床生化参数进行了评估:方法:简而言之,采用实时聚合酶链反应(RT-PCR)确认 SARS-CoV-2 感染。采用分光光度法和化学发光微粒子免疫测定法(CMIA)的原理估测感染者血清中葡萄糖、促甲状腺激素和 25-羟基维生素 D 的水平:这项横断面研究共选取了 236 名 SARS-CoV-2 感染者。COVID-19患者中男性居多(72.9%对27.1%),25-羟基维生素D缺乏症的发病率较高(72.0%对28.0%),平均25-羟基维生素D水平为24.0±13.9纳克/毫升。我们观察到,SARS-CoV-2 感染的临床表现多种多样,轻度、中度和重度患者分别占 36.4%、23.7% 和 29.7%。我们观察到,SARS-CoV-2 感染的严重程度与高龄、高血压、低促甲状腺激素水平和 25- 羟基维生素 D 缺乏症明显相关:结论:我们得出的结论是,不仅年龄大,高血压、促甲状腺激素水平低和 25-羟维生素 D 水平低也会明显导致 SARS-CoV-2 感染的临床严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Age and Clinico-Biochemical Parameters on Clinical Severity of SARS-CoV-2 Infection.

Introduction: The surge in novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to coronavirus disease-2019 (COVID-19) has overwhelmed the health system. To help health-care workers and policy makers prioritize treatment and to decrease the burden on health systems caused by COVID-19, clinical severity along with various clinico-biochemical parameters was evaluated by designing a cross-sectional study comprising 236 SARS-CoV-2-infected individuals from Kashmir Valley, India.

Methods: Briefly, real-time polymerase chain reaction (RT-PCR) was used for the confirmation of SARS-CoV-2 infection. The principles of spectrophotometry and chemiluminescent microparticle immunoassay (CMIA) were employed to estimate the levels of glucose, TSH, and 25-hydroxy vitamin D levels in serum of infected patients.

Results: A total of 236 patients infected with SARS-CoV-2 were taken for this cross-sectional study. Patients with COVID-19 had a male predominance (72.9 vs. 27.1%) and a higher prevalence of 25-hydroxy vitamin D deficiency (72.0 vs. 28.0%) with a mean 25-hydroxy vitamin D levels of 24.0 ± 13.9 in ng/mL. We observed a varied clinical spectrum of SARS-CoV-2 infection with 36.4%, 23.7%, and 29.7% patients having mild, moderate, and severe disease, respectively. We observed that severity of SARS-CoV-2 infection was significantly associated with older age group, hypertension, low TSH levels, and 25-hydroxy vitamin D deficiency.

Conclusion: We conclude that not only old age but also hypertension and low levels of TSH and 25-hydroxy vitamin D levels could significantly lead to clinical severity of SARS-CoV-2 infection.

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来源期刊
Intervirology
Intervirology 医学-病毒学
CiteScore
5.40
自引率
0.00%
发文量
13
审稿时长
6-12 weeks
期刊介绍: ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.
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