哮喘预测工具在一组患有严重毛细支气管炎的婴儿中的应用。

IF 1.1 4区医学 Q4 ALLERGY

Pediatric Allergy Immunology and Pulmonology Pub Date : 2023-09-01 Epub Date: 2023-08-28 DOI:10.1089/ped.2023.0016

Ronaldo C Fabiano Filho, Ruth J Geller, Ludmilla Candido Santos, Janice A Espinola, Lacey B Robinson, Carlos A Camargo

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引用次数: 0

摘要

背景：严重细支气管炎是儿童哮喘的一个重要危险因素。早期准确的哮喘预测是关键。我们在一组高危婴儿中应用了哮喘预测指数（API）、改良哮喘预测指标（mAPI）和儿科哮喘风险评分（PARS）来预测6岁时的哮喘。方法：我们对17个中心的婴儿队列进行了研究。结果：6岁时父母报告的哮喘患病率为328/880（37%）。严格和宽松的API、mAPI和PARS的阳性指数/得分的发生率分别为21%、51%、11%和34%。受试者工作特性曲线下面积[95%置信区间（CI）]范围从mAPI的0.57（95%CI 0.55-0.60）到PARS的0.66（95%CI 0.63-0.70）。结论：需要一种针对高危婴儿的哮喘预测工具，以确定那些从哮喘预防干预中受益最大的婴儿。

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Application of Asthma Prediction Tools in a Cohort of Infants with Severe Bronchiolitis.

Background: Severe bronchiolitis is a strong childhood asthma risk factor. Early and accurate asthma prediction is key. We applied the Asthma Predictive Index (API), the modified Asthma Predictive Index (mAPI), and the Pediatric Asthma Risk Score (PARS) in a cohort of high-risk infants to predict asthma at age 6 years. Methods: We conducted a 17-center cohort of infants (age <1 year) hospitalized with severe bronchiolitis during 2011-2014. We used only infancy data to predict asthma at age 6 years. Results: The prevalence of parent-reported asthma at age 6 years was 328/880 (37%). The prevalences of a positive index/score for stringent and loose API, mAPI, and PARS were 21%, 51%, 11%, and 34%, respectively. Area under the receiver operating characteristic curves [95% confidence interval (CI)] ranged from 0.57 (95% CI 0.55-0.60) for mAPI to 0.66 (95% CI 0.63-0.70) for PARS. Conclusions: An asthma prediction tool for high-risk infants is needed to identify those who would benefit most from asthma prevention interventions.

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来源期刊

Pediatric Allergy Immunology and Pulmonology ALLERGY-IMMUNOLOGY

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Allergy, Immunology, and Pulmonology is a peer-reviewed journal designed to promote understanding and advance the treatment of respiratory, allergic, and immunologic diseases in children. The Journal delivers original translational, clinical, and epidemiologic research on the most common chronic illnesses of children—asthma and allergies—as well as many less common and rare diseases. It emphasizes the developmental implications of the morphological, physiological, pharmacological, and sociological components of these problems, as well as the impact of disease processes on families. Pediatric Allergy, Immunology, and Pulmonology coverage includes: -Functional and genetic immune deficiencies- Interstitial lung diseases- Both common and rare respiratory, allergic, and immunologic diseases- Patient care- Patient education research- Public health policy- International health studies