Tatiana Schäffer Gregianini, Richard Steiner Salvato, Regina Bones Barcellos, Fernanda Marques Godinho, Amanda Pellenz Ruivo, Viviane Horn de Melo, Júlio Augusto Schroder, Fernanda Letícia Martiny, Erica Bortoli Möllmann, Cátia Favreto, Ludmila Fiorenzano Baethgen, Vithoria Pompermaier Ferreira, Lívia Eidt de Lima, Cláudia Fasolo Piazza, Taís Raquel Marcon Machado, Irina Marieta Becker, Raquel Rocha Ramos, Guilherme Carey Frölich, Alana Fraga Rossetti, Lucas da Cunha Almeida, Tahiana Machado Antunes Rodrigues, Isabella Tabelli Bragança, Aline Alves Scarpellini Campos, Verônica Baú Manzoni, Lais Ceschini Machado, Luisa Maria Inácio da Silva, André Luiz Sá de Oliveira, Marcelo Henrique Santos Paiva, Zenaida Marion Alves Nunes, Paula Rodrigues de Almeida, Meriane Demoliner, Juliana Schons Gularte, Mariana Soares da Silva, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Fernando Rosado Spilki, Ana Beatriz Gorini da Veiga, Gabriel Luz Wallau
{"title":"基孔肯雅病毒感染在巴西最南端州的特点是自我限制传播(2017-2019年)和2021年更大规模的暴发。","authors":"Tatiana Schäffer Gregianini, Richard Steiner Salvato, Regina Bones Barcellos, Fernanda Marques Godinho, Amanda Pellenz Ruivo, Viviane Horn de Melo, Júlio Augusto Schroder, Fernanda Letícia Martiny, Erica Bortoli Möllmann, Cátia Favreto, Ludmila Fiorenzano Baethgen, Vithoria Pompermaier Ferreira, Lívia Eidt de Lima, Cláudia Fasolo Piazza, Taís Raquel Marcon Machado, Irina Marieta Becker, Raquel Rocha Ramos, Guilherme Carey Frölich, Alana Fraga Rossetti, Lucas da Cunha Almeida, Tahiana Machado Antunes Rodrigues, Isabella Tabelli Bragança, Aline Alves Scarpellini Campos, Verônica Baú Manzoni, Lais Ceschini Machado, Luisa Maria Inácio da Silva, André Luiz Sá de Oliveira, Marcelo Henrique Santos Paiva, Zenaida Marion Alves Nunes, Paula Rodrigues de Almeida, Meriane Demoliner, Juliana Schons Gularte, Mariana Soares da Silva, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Fernando Rosado Spilki, Ana Beatriz Gorini da Veiga, Gabriel Luz Wallau","doi":"10.1590/0074-02760220259","DOIUrl":null,"url":null,"abstract":"BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e220259"},"PeriodicalIF":2.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392894/pdf/","citationCount":"0","resultStr":"{\"title\":\"Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak.\",\"authors\":\"Tatiana Schäffer Gregianini, Richard Steiner Salvato, Regina Bones Barcellos, Fernanda Marques Godinho, Amanda Pellenz Ruivo, Viviane Horn de Melo, Júlio Augusto Schroder, Fernanda Letícia Martiny, Erica Bortoli Möllmann, Cátia Favreto, Ludmila Fiorenzano Baethgen, Vithoria Pompermaier Ferreira, Lívia Eidt de Lima, Cláudia Fasolo Piazza, Taís Raquel Marcon Machado, Irina Marieta Becker, Raquel Rocha Ramos, Guilherme Carey Frölich, Alana Fraga Rossetti, Lucas da Cunha Almeida, Tahiana Machado Antunes Rodrigues, Isabella Tabelli Bragança, Aline Alves Scarpellini Campos, Verônica Baú Manzoni, Lais Ceschini Machado, Luisa Maria Inácio da Silva, André Luiz Sá de Oliveira, Marcelo Henrique Santos Paiva, Zenaida Marion Alves Nunes, Paula Rodrigues de Almeida, Meriane Demoliner, Juliana Schons Gularte, Mariana Soares da Silva, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Fernando Rosado Spilki, Ana Beatriz Gorini da Veiga, Gabriel Luz Wallau\",\"doi\":\"10.1590/0074-02760220259\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.\",\"PeriodicalId\":18469,\"journal\":{\"name\":\"Memorias do Instituto Oswaldo Cruz\",\"volume\":\"118 \",\"pages\":\"e220259\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392894/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Memorias do Instituto Oswaldo Cruz\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1590/0074-02760220259\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Memorias do Instituto Oswaldo Cruz","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/0074-02760220259","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak.
BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.
期刊介绍:
Memórias do Instituto Oswaldo Cruz is a journal specialized in microbes & their vectors causing human infections. This means that we accept manuscripts covering multidisciplinary approaches and findings in the basic aspects of infectious diseases, e.g. basic in research in prokariotes, eukaryotes, and/or virus. Articles must clearly show what is the main question to be answered, the hypothesis raised, and the contribution given by the study.
Priority is given to manuscripts reporting novel mechanisms and general findings concerning the biology of human infectious prokariotes, eukariotes or virus. Papers reporting innovative methods for diagnostics or that advance the basic research with these infectious agents are also welcome.
It is important to mention what we do not publish: veterinary infectious agents research, taxonomic analysis and re-description of species, epidemiological studies or surveys or case reports and data re-analysis. Manuscripts that fall in these cases or that are considered of low priority by the journal editorial board, will be returned to the author(s) for submission to another journal.