建议的悉尼系统报告淋巴结细胞病理学的应用:南印度一个学术机构的五年经验。

IF 1.6 4区 医学 Q3 PATHOLOGY
Acta Cytologica Pub Date : 2023-01-01 DOI:10.1159/000530038
Sakthisankari Shanmugasundaram, Nandhini Bala Balasubramanian, Abinaya Sundari Amirthakatesan
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引用次数: 0

摘要

细针穿刺活检(FNAB)是评估淋巴结病理的常规检查方法。然而,由于缺乏标准指南,细胞病理学报告缺乏统一性。最近,一种新的报告淋巴结细胞病理学的系统被提出。本研究旨在分析该系统在我院细胞病理报告中的应用。资料:5年内进行的淋巴结fnab按照拟议的Sydney系统进行分类。将细胞病理学诊断与组织病理学诊断相比较,评价诊断的准确性。计算每个类别的恶性肿瘤发生率(ROM)。结果:共纳入747例淋巴结fnab。262例进行组织病理学检查。I-V类的ROM分别为26.3%、7.2%、76.9%、82.3%和100.0%。考虑L3分类代表良性细胞病理时,FNAB的敏感性为84.2%,特异性为97.5%,阳性预测值为97.1%,阴性预测值为86.2%。考虑L3类代表恶性细胞病理时,FNAB的敏感性为92.56%,特异性为95.08%,阳性预测值为94.9%,阴性预测值为92.8%。结论:该研究证实了在淋巴结细胞病理学中提出的悉尼系统在加强临床医生和细胞病理学家之间更好的沟通方面的有用性。使用辅助技术,如免疫细胞化学和流式细胞术将有助于达到更精确的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Application of the Proposed Sydney System for Reporting Lymph Node Cytopathology: A Five-Year Experience of an Academic Institution in South India.

Introduction: Fine needle aspiration biopsy (FNAB) is a routinely used investigation in the evaluation of lymph node pathologies. However, there exists a lack of uniformity in cytopathology reporting owing to the nonavailability of standard guidelines. Recently, a novel system for reporting lymph node cytopathology has been proposed. The present study aimed to analyze the utility of the proposed system in cytopathology reporting in our institution.

Materials: FNABs of lymph nodes performed over a period of 5 years were categorized as per the proposed Sydney system. The diagnoses on cytopathology were correlated with histopathologic diagnoses to assess the diagnostic accuracy. The rate of malignancy (ROM) for each category was calculated.

Results: A total of 747 lymph node FNABs were included in the study. Histopathology was available in 262 cases. ROM in categories I-V was 26.3%, 7.2%, 76.9%, 82.3%, and 100.0%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of FNAB when considering category L3 to represent benign cytopathology were 84.2%, 97.5%, 97.1%, and 86.2%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of FNAB when considering category L3 to represent malignant cytopathology were 92.56%, 95.08%, 94.9%, and 92.8%, respectively.

Conclusion: The study substantiates the usefulness of the proposed Sydney system in lymph node cytopathology in enhancing better communication between clinicians and cytopathologists. The use of ancillary techniques like immunocytochemistry and flow cytometry will aid in arriving at a more precise diagnosis.

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来源期刊
Acta Cytologica
Acta Cytologica 生物-病理学
CiteScore
3.70
自引率
11.10%
发文量
46
审稿时长
4-8 weeks
期刊介绍: With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.
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