丙型肝炎病毒进入的遗传和药理学扰动

IF 5.7 2区 医学 Q1 VIROLOGY
Belén Carriquí-Madroñal , Lisa Lasswitz , Thomas von Hahn , Gisa Gerold
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引用次数: 1

摘要

丙型肝炎病毒(HCV)在全球范围内慢性感染5800万人,其疾病结果各不相同。虽然接触病毒的个体中有一小部分可以清除感染,但如果不治疗,大多数会发展为慢性感染。慢性病的另一个亚组分发展为严重的肝病。这种个体间变异的根本原因包括干扰素基因的遗传多态性。在此,我们回顾了关于HCV宿主依赖性因素的遗传或药理学干扰对临床观察到的疾病结果个体间差异的影响的现有数据。我们专注于介导病毒进入人类肝细胞的宿主因子。我们评估了主要进入因子清除剂受体B类I型、CD81、claudin-1和occludin的遗传变异以及这些进入因子的药理学扰动的可用数据。我们回顾了细胞培养实验和临床队列研究数据,并得出结论,进入因子干扰可能有助于丙型肝炎的疾病结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic and pharmacological perturbation of hepatitis-C virus entry

Hepatitis-C virus (HCV) chronically infects 58 million individuals worldwide with variable disease outcome. While a subfraction of individuals exposed to the virus clear the infection, the majority develop chronic infection if untreated. Another subfraction of chronically ill proceeds to severe liver disease. The underlying causes of this interindividual variability include genetic polymorphisms in interferon genes. Here, we review available data on the influence of genetic or pharmacological perturbation of HCV host dependency factors on the clinically observed interindividual differences in disease outcome. We focus on host factors mediating virus entry into human liver cells. We assess available data on genetic variants of the major entry factors scavenger receptor class-B type I, CD81, claudin-1, and occludin as well as pharmacological perturbation of these entry factors. We review cell culture experimental and clinical cohort study data and conclude that entry factor perturbation may contribute to disease outcome of hepatitis C.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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