人越多越好?灵长类慢病毒与其宿主共同进化中的基因复制

IF 5.7 2区 医学 Q1 VIROLOGY
Martin Müller, Daniel Sauter
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引用次数: 0

摘要

基因重复是遗传多样性和进化创新的主要来源。新形成的重复基因可以在不断变化的环境中提供选择优势。一个这样的例子是艾滋病毒和相关慢病毒与宿主的先天免疫反应的军备竞赛。近年来,很明显,双方都从多重基因复制中受益。例如,抗逆转录病毒因子的扩增,如载脂蛋白-B信使核糖核酸编辑酶催化多肽-3(APOBEC3)、干扰素诱导的跨膜蛋白(IFITM)和含有三重基序(TRIM)的蛋白,扩大了细胞内在防御机制的库,增加了反转录病毒复制和跨物种传播的障碍。相反,最近的研究也揭示了副慢病毒基因和长末端重复序列(LTR)元件的重复如何在与抗病毒宿主蛋白的共同进化中提供选择优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The more the merrier? Gene duplications in the coevolution of primate lentiviruses with their hosts

The more the merrier? Gene duplications in the coevolution of primate lentiviruses with their hosts

Gene duplications are a major source of genetic diversity and evolutionary innovation. Newly formed, duplicated genes can provide a selection advantage in constantly changing environments. One such example is the arms race of HIV and related lentiviruses with innate immune responses of their hosts. In recent years, it has become clear that both sides have benefited from multiple gene duplications. For example, amplifications of antiretroviral factors such as apolipoprotein-B mRNA-editing enzyme catalytic polypeptide-3 (APOBEC3), interferon-induced transmembrane protein (IFITM), and tripartite motif-containing (TRIM) proteins have expanded the repertoire of cell-intrinsic defense mechanisms and increased the barriers to retroviral replication and cross-species transmission. Conversely, recent studies have also shed light on how duplications of accessory lentiviral genes and Long terminal repeat (LTR) elements can provide a selection advantage in the coevolution with antiviral host proteins.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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