红细胞生成末期和粒细胞生成末期在其共同的生态位(红细胞母细胞岛)中相互交织。

IF 3.1 3区 医学 Q2 HEMATOLOGY
Current Opinion in Hematology Pub Date : 2023-07-01 Epub Date: 2023-04-25 DOI:10.1097/MOH.0000000000000767
Laurel Romano, Katie G Seu, Lionel Blanc, Theodosia A Kalfa
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引用次数: 0

摘要

综述的目的:自从红细胞生成岛(EBI)巨噬细胞(Mϕ)被认为是 "哺育 "末端红细胞生成的第一个造血生态位以来,人们对它的身份进行了数十年的研究。本综述将重点介绍目前对 EBI 巨噬细胞平衡末端红细胞生成和粒细胞生成的特征和作用的认识:尽管 EBI 长期以来一直被认为是红细胞前体的龛位,但生物学研究技术的重大进步,包括 EBI 富集方案的优化、单细胞核糖核酸测序和成像流式细胞术,最近揭示了粒细胞前体也共存于这一龛位,即红细胞母细胞岛(EMBI)。更重要的是,在影响造血的疾病(如应激性红细胞生成和导致炎症性贫血的炎症性疾病)中,EBI/EMBI 内的末端粒细胞生成和红细胞生成之间的基线平衡会发生改变。然而,EMBI Mϕ 的转录和细胞表面标志物异质性程度显著,这表明它具有可塑性和多种功能。摘要:末端红细胞生成和粒细胞生成受 EMBI 调节。对它们在健康和疾病中的平衡进行研究,可能会发现治疗末端造血疾病的新靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crosstalk between terminal erythropoiesis and granulopoiesis within their common niche: the erythromyeloblastic island.

Purpose of review: The identity of the erythroblastic island (EBI) macrophage (Mϕ) has been under investigation for decades since it was recognized as the first hematopoietic niche 'nursing' terminal erythropoiesis. This review will focus on the current insights to the characteristics and the role of the EBI Mϕ balancing terminal erythropoiesis and granulopoiesis.

Recent findings: While the EBI has long been known as the niche for erythroid precursors, significant advancements in biology research technologies, including optimization of EBI enrichment protocols, single-cell ribonucleic acid sequencing, and imaging flow cytometry, have recently revealed that granulocytic precursors co-exist in this niche, termed erythromyeloblastic island (EMBI). More importantly, the balance noted at baseline between terminal granulopoiesis and erythropoiesis within EBIs/EMBIs is altered with diseases affecting hematopoiesis, such as stress erythropoiesis and inflammatory conditions causing anemia of inflammation. The role of the EMBI niche has yet to be fully investigated mechanistically, however, a notable degree of transcriptional and cell surface marker heterogeneity has been identified for the EMBI Mϕ, implicating its plasticity and diverse function.

Summary: Terminal erythropoiesis and granulopoiesis are regulated within the EMBI. Investigations of their balance within this niche in health and disease may reveal new targets for treatment of diseases of terminal hematopoiesis.

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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.
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