免疫检查点抑制剂治疗后曲霉和沙门氏菌引起的坏死性肺炎:一个不寻常的病例和文献回顾

IF 1.5 4区 生物学 Q4 MYCOLOGY
Muhammed Cihan Işık , Oğuz Karcıoğlu , Gülşen Hazırolan , Dolunay Gülmez , Mehmet Ruhi Onur , Mehmet Mahir Kunt , Sevtap Arikan-Akdagli , Gökhan Metan
{"title":"免疫检查点抑制剂治疗后曲霉和沙门氏菌引起的坏死性肺炎:一个不寻常的病例和文献回顾","authors":"Muhammed Cihan Işık ,&nbsp;Oğuz Karcıoğlu ,&nbsp;Gülşen Hazırolan ,&nbsp;Dolunay Gülmez ,&nbsp;Mehmet Ruhi Onur ,&nbsp;Mehmet Mahir Kunt ,&nbsp;Sevtap Arikan-Akdagli ,&nbsp;Gökhan Metan","doi":"10.1016/j.riam.2023.05.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Immune checkpoint inhibitors (ICIs) are a promising new treatment for different types of cancer. The infectious complications in patients taking ICIs are rare.</p></div><div><h3>Case report</h3><p><span>A 58-year-old male who received chemotherapy consisting of pembrolizumab (PD-1 inhibitor) for esophagus squamous cell carcinoma one month before was admitted to the emergency room with shortness of breath soon after fiberoptic bronchoscopy, which was done for the inspection of the lower airway. A computed tomography of the chest revealed a progressive consolidation on the right upper lobe. </span><em>Salmonella</em> group D was isolated from the bronchoalveolar lavage (BAL) fluid culture. The fungal culture of the same clinical sample yielded <span><span>Aspergillus niger</span></span>; furthermore, a high titer (above the cut-off values) of <em>Aspergillus</em> antigen was found both in the BAL fluid and serum of the patient. Despite the effective spectrum and appropriate dose of antimicrobial treatment, the patient died due to disseminated intravascular coagulopathy.</p></div><div><h3>Conclusions</h3><p>Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature\",\"authors\":\"Muhammed Cihan Işık ,&nbsp;Oğuz Karcıoğlu ,&nbsp;Gülşen Hazırolan ,&nbsp;Dolunay Gülmez ,&nbsp;Mehmet Ruhi Onur ,&nbsp;Mehmet Mahir Kunt ,&nbsp;Sevtap Arikan-Akdagli ,&nbsp;Gökhan Metan\",\"doi\":\"10.1016/j.riam.2023.05.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Immune checkpoint inhibitors (ICIs) are a promising new treatment for different types of cancer. The infectious complications in patients taking ICIs are rare.</p></div><div><h3>Case report</h3><p><span>A 58-year-old male who received chemotherapy consisting of pembrolizumab (PD-1 inhibitor) for esophagus squamous cell carcinoma one month before was admitted to the emergency room with shortness of breath soon after fiberoptic bronchoscopy, which was done for the inspection of the lower airway. A computed tomography of the chest revealed a progressive consolidation on the right upper lobe. </span><em>Salmonella</em> group D was isolated from the bronchoalveolar lavage (BAL) fluid culture. The fungal culture of the same clinical sample yielded <span><span>Aspergillus niger</span></span>; furthermore, a high titer (above the cut-off values) of <em>Aspergillus</em> antigen was found both in the BAL fluid and serum of the patient. Despite the effective spectrum and appropriate dose of antimicrobial treatment, the patient died due to disseminated intravascular coagulopathy.</p></div><div><h3>Conclusions</h3><p>Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.</p></div>\",\"PeriodicalId\":21291,\"journal\":{\"name\":\"Revista Iberoamericana De Micologia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Iberoamericana De Micologia\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1130140623000098\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MYCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Iberoamericana De Micologia","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1130140623000098","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

免疫检查点抑制剂(ICIs)是一种很有前景的治疗不同类型癌症的新方法。注射ICIs患者的感染并发症很少见。病例报告:一名58岁男性患者在一个月前接受了由派姆单抗(PD-1抑制剂)组成的食管鳞状细胞癌化疗,在进行纤维支气管镜检查后不久因呼吸急促而入住急诊室,该检查是为了检查下气道。胸部计算机断层扫描显示右上肺叶进行性实变。从支气管肺泡灌洗(BAL)液培养中分离出D组沙门氏菌。同一临床样品的真菌培养产生黑曲霉;此外,在患者的BAL液和血清中发现了高滴度(高于临界值)的曲霉抗原。尽管抗菌药物治疗有效且剂量合适,患者还是死于弥散性血管内凝血病。结论对ICI治疗后肺炎病因中异常病原体的认识有助于避免漏诊。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature

Background

Immune checkpoint inhibitors (ICIs) are a promising new treatment for different types of cancer. The infectious complications in patients taking ICIs are rare.

Case report

A 58-year-old male who received chemotherapy consisting of pembrolizumab (PD-1 inhibitor) for esophagus squamous cell carcinoma one month before was admitted to the emergency room with shortness of breath soon after fiberoptic bronchoscopy, which was done for the inspection of the lower airway. A computed tomography of the chest revealed a progressive consolidation on the right upper lobe. Salmonella group D was isolated from the bronchoalveolar lavage (BAL) fluid culture. The fungal culture of the same clinical sample yielded Aspergillus niger; furthermore, a high titer (above the cut-off values) of Aspergillus antigen was found both in the BAL fluid and serum of the patient. Despite the effective spectrum and appropriate dose of antimicrobial treatment, the patient died due to disseminated intravascular coagulopathy.

Conclusions

Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信