Ruoyu Li , Yungshan Teng , Yuqing Guo , Jianhan Ren , Runze Li , Haotian Luo , Danying Chen , Zhicai Feng , Zheng Fu , Xuenong Zou , Weicai Wang , Chen Zhou
{"title":"脂肪来源干细胞中组蛋白甲基转移酶SUV39H1的衰老相关降低增强了SASP。","authors":"Ruoyu Li , Yungshan Teng , Yuqing Guo , Jianhan Ren , Runze Li , Haotian Luo , Danying Chen , Zhicai Feng , Zheng Fu , Xuenong Zou , Weicai Wang , Chen Zhou","doi":"10.1016/j.mad.2023.111868","DOIUrl":null,"url":null,"abstract":"<div><p>Aging-related diseases are closely associated with the state of inflammation, which is known as “inflammaging.” Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed the senescence-associated secretory phenotype (SASP). Epigenetic regulation, especially the structural regulation of chromatin, is closely linked to the regulation of SASP. In our previous study, the suppressor of variegation 3–9 homolog 1 (<em>SUV39H1)</em> was elucidated to interact with Lhx8 and determine the cell fate of mesenchyme stem cells. However, the function of <em>SUV39H1</em> during aging and the underlying mechanism of its epigenetic regulation remains controversial. Therefore, the C57BL/6 J <em>CAG-Cre; SUV39H1</em><sup><em>fl/fl</em></sup> knockout mice and irradiation-induced cellular senescence model were built in this study to deepen the understanding of epigenetic regulation by <em>SUV39H1</em> and its relation to SASP. In vivo and in vitro studies demonstrated that <em>SUV39H1</em> decreased with aging and served as an inhibitor of SASP, especially IL-6, MCP-1, and Vcam-1, by altering H3K9me3 enrichment in their promoter region. These results provide new insights into the epigenetic regulation of SASP.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"215 ","pages":"Article 111868"},"PeriodicalIF":5.3000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP\",\"authors\":\"Ruoyu Li , Yungshan Teng , Yuqing Guo , Jianhan Ren , Runze Li , Haotian Luo , Danying Chen , Zhicai Feng , Zheng Fu , Xuenong Zou , Weicai Wang , Chen Zhou\",\"doi\":\"10.1016/j.mad.2023.111868\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Aging-related diseases are closely associated with the state of inflammation, which is known as “inflammaging.” Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed the senescence-associated secretory phenotype (SASP). Epigenetic regulation, especially the structural regulation of chromatin, is closely linked to the regulation of SASP. In our previous study, the suppressor of variegation 3–9 homolog 1 (<em>SUV39H1)</em> was elucidated to interact with Lhx8 and determine the cell fate of mesenchyme stem cells. However, the function of <em>SUV39H1</em> during aging and the underlying mechanism of its epigenetic regulation remains controversial. Therefore, the C57BL/6 J <em>CAG-Cre; SUV39H1</em><sup><em>fl/fl</em></sup> knockout mice and irradiation-induced cellular senescence model were built in this study to deepen the understanding of epigenetic regulation by <em>SUV39H1</em> and its relation to SASP. In vivo and in vitro studies demonstrated that <em>SUV39H1</em> decreased with aging and served as an inhibitor of SASP, especially IL-6, MCP-1, and Vcam-1, by altering H3K9me3 enrichment in their promoter region. These results provide new insights into the epigenetic regulation of SASP.</p></div>\",\"PeriodicalId\":18340,\"journal\":{\"name\":\"Mechanisms of Ageing and Development\",\"volume\":\"215 \",\"pages\":\"Article 111868\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mechanisms of Ageing and Development\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0047637423000945\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mechanisms of Ageing and Development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0047637423000945","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP
Aging-related diseases are closely associated with the state of inflammation, which is known as “inflammaging.” Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed the senescence-associated secretory phenotype (SASP). Epigenetic regulation, especially the structural regulation of chromatin, is closely linked to the regulation of SASP. In our previous study, the suppressor of variegation 3–9 homolog 1 (SUV39H1) was elucidated to interact with Lhx8 and determine the cell fate of mesenchyme stem cells. However, the function of SUV39H1 during aging and the underlying mechanism of its epigenetic regulation remains controversial. Therefore, the C57BL/6 J CAG-Cre; SUV39H1fl/fl knockout mice and irradiation-induced cellular senescence model were built in this study to deepen the understanding of epigenetic regulation by SUV39H1 and its relation to SASP. In vivo and in vitro studies demonstrated that SUV39H1 decreased with aging and served as an inhibitor of SASP, especially IL-6, MCP-1, and Vcam-1, by altering H3K9me3 enrichment in their promoter region. These results provide new insights into the epigenetic regulation of SASP.
期刊介绍：
Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms.
Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.
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