The long-term success of periodontal regeneration: a 10-year follow-up case report.

BACKGROUND The predictability and long-term success of periodontal regeneration begins with oral hygiene education, disease management, and individually tailored periodontal maintenance protocol. The treatment outcomes could be enhanced when biologics and bone grafts are combined. The aim of this report is to describe the outcome of two complex infrabony defects in the same patient treated with recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and freeze-dried bone allograft (FDBA) over 10 years. CASE PRESENTATION Two complex infrabony defects treated following guided tissue regeneration principles and procedures. Full-thickness flaps were raised to allow visualization of the defects. The areas were debrided, and exposed root surfaces were planed. FDBA and rhPDGF-BB were combined to fill both defects. A collagen membrane was used over the bone graft in one case. The flaps were reapproximated to achieve primary closure. The patients were seen for regular periodontal maintenance visits and clinical and radiographic follow-ups over 10 years. Throughout the examination periods, the probing depths improved without bleeding on probing, and there was radiographic evidence of bone regeneration. CONCLUSION The growth factor-infused bone graft was successfully utilized for periodontal regeneration in complex bony defects.