研究精神分裂症突触功能障碍和认知的人类干细胞模型：叙述性综述。

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2024-11-01 DOI:10.1016/j.schres.2023.02.029

Stephanie Santarriaga , Kaia Gerlovin , Yasmine Layadi , Rakesh Karmacharya

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引用次数: 0

摘要

认知障碍是精神分裂症功能性结果的最有力预测因素，据推测，认知障碍是突触功能障碍的结果。然而，针对患者的突触可塑性和认知障碍仍然是一项重大的临床挑战。全面了解疾病背景下的突触可塑性以及学习和记忆的分子基础，可以为开发针对精神分裂症认知障碍的新型疗法提供特定靶点。在此，我们描述了突触可塑性在认知中的作用，总结了精神分裂症突触功能障碍的证据，并展示了如何利用患者诱导多能干细胞在体外研究突触可塑性。最后，我们讨论了将突触功能障碍的基础科学研究与临床和转化研究连接起来的当前进展和未来技术，这些研究可用于预测治疗反应和开发新型疗法。

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Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review

Cognitive impairment is the strongest predictor of functional outcomes in schizophrenia and is hypothesized to result from synaptic dysfunction. However, targeting synaptic plasticity and cognitive deficits in patients remains a significant clinical challenge. A comprehensive understanding of synaptic plasticity and the molecular basis of learning and memory in a disease context can provide specific targets for the development of novel therapeutics targeting cognitive impairments in schizophrenia. Here, we describe the role of synaptic plasticity in cognition, summarize evidence for synaptic dysfunction in schizophrenia and demonstrate the use of patient derived induced-pluripotent stem cells for studying synaptic plasticity in vitro. Lastly, we discuss current advances and future technologies for bridging basic science research of synaptic dysfunction with clinical and translational research that can be used to predict treatment response and develop novel therapeutics.

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.