海洋海绵真菌曲霉产生的抗菌含氧麦角固醇类固醇

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI:10.1080/10286020.2023.2259317

Hui-Min Wen , Ya-Wen Zhang , Fang-Jian Feng , Guo-Bao Huang , Yu-Han Lv , Zou-Yan Zhang , Li-Jian Ding

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引用次数: 0

摘要

从海洋海绵衍生真菌曲霉（Aspergillus sp）的粗提取物中分离出两种含氧麦角甾烷类固醇，包括一种新化合物 3β-羟基-5α,6β-甲氧基麦角甾烷-7,22-二烯-15-酮（1）和一种已知类似物麦角甾烷-6,22-二烯-3β,5α,8α-三醇（2）。化合物 1 是一种海洋麦角甾类化合物，其 C-5 和 C-6 分别含有两个甲氧基。这些含氧麦角甾烷类化合物对人类或水生病原体的抗菌活性进行了评估。其中，化合物 1 对金黄色葡萄球菌具有抗菌活性。

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Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp.

Two oxygenated ergostane-type steroids including one new compound, 3β-hydroxy-5α,6β-methoxyergosta-7,22-dien-15-one (1) along with a known analogue ergosta-6,22-dien-3β,5α,8α-triol (2) were isolated from the crude extracts of the marine sponge-derived fungus Aspergillus sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound 1 was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound 1 exhibited antibacterial activity against Staphylococcus aureus.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.