大鼠更喜欢炼乳而不是草莓酱--自愿口服药物的一种新可能性。

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Laboratory Animals Pub Date : 2024-04-01 Epub Date: 2023-09-15 DOI:10.1177/00236772231194389

Mariana Ferreira-Duarte, Igor Moreira Lopes, Manuela Morato, Margarida Duarte-Araújo

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引用次数: 0

摘要

使用甜味物质进行自愿口服给药可提高啮齿动物的治疗依从性，同时减少强制给药引起的应激反应。我们的目的是测试大鼠是否愿意从注射器中吃草莓酱或炼乳，以及它们更喜欢哪一种。我们的结果表明，大鼠更喜欢炼乳，这表明炼乳有可能成为实验方案中自愿口服给药的载体。

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Rats prefer condensed milk to strawberry jam - a new possibility for voluntary oral drug administration.

Voluntary oral drug administration using sweet substances promotes rodents' therapeutic compliance while reducing stress induced by forced drug administration. We aimed to test whether rats would willingly eat strawberry jam or condensed milk from a syringe, and which one they would prefer. Our results show that rats prefer condensed milk, demonstrating its potential as a vehicle for the voluntary oral administration of drugs in experimental protocols.

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来源期刊

Laboratory Animals 生物-动物学

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.