乙醇脱氢酶7基因多态性与镰状细胞病的急性和慢性疼痛相关。

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacogenomics Pub Date : 2023-08-01 Epub Date: 2023-09-15 DOI:10.2217/pgs-2023-0084

Yavnika Kashyap, Ying He, Nilanjana Sadhu, Yingwei Yao, Diana J Wilkie, Robert E Molokie, Zaijie Jim Wang

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引用次数: 0

摘要

引言：作为镰状细胞病（SCD）最令人痛苦的并发症，疼痛具有相当大的异质性。在本研究中，我们探讨了乙醇脱氢酶7基因（ADH7）多态性rs971074与镰状细胞疼痛的潜在关联。方法：我们通过MassARRAY iPlex分析分析了SCD患者的临床表型和ADH7的rs971074单核苷酸多态性。结果：同义rs971074与SCD的急性和慢性疼痛均显著相关。具有次要T等位基因的患者记录到明显更多的危象发作和严重的慢性疼痛症状。结论：我们的研究已经确定rs971074小T等位基因是一种可能影响急性和慢性疼痛的遗传生物标志物。这些发现可能最终有助于制定SCD精确疼痛疗法的策略。

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An alcohol dehydrogenase 7 gene polymorphism associates with both acute and chronic pain in sickle cell disease.

Introduction: As the most distressing complication of sickle cell disease (SCD), pain is marked by considerable heterogenicity. In this study we explored the potential association of alcohol dehydrogenase 7 gene (ADH7) polymorphism rs971074 with sickle cell pain. Methods: We analyzed clinical phenotypes and the rs971074 single-nucleotide polymorphism in ADH7 by MassARRAY-iPlex analysis in a cohort of SCD patients. Results: The synonymous rs971074 was significantly associated with both acute and chronic pain in SCD. Patients with the minor T allele(s) recorded significantly more crisis episodes and severe chronic pain symptoms. Conclusion: Our study has identified the rs971074 minor T allele as a genetic biomarker potentially influencing acute and chronic pain. These findings may ultimately help inform strategies to develop precision pain therapies in SCD.

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.