运动介导前列腺癌中独立于雄激素信号的肌因子释放和肿瘤抑制。

IF 4.7 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2023-10-01 Epub Date: 2023-06-07 DOI:10.1249/JES.0000000000000323

Jin-Soo Kim, Dennis R Taaffe, Daniel A Galvão, Fred Saad, Robert U Newton

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引用次数: 0

摘要

前列腺癌症（PCa）患者雄激素抑制的一个突出毒性是骨骼肌的丧失。运动可能通过骨骼肌的内分泌功能诱导肿瘤抑制；然而，这一点目前尚不清楚。在这篇综述中，我们总结了我们的工作，证明了PCa患者对运动的急性和慢性肌细胞因子反应以及循环环境改变的肿瘤抑制作用。

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Exercise Mediates Myokine Release and Tumor Suppression in Prostate Cancer Independent of Androgen Signaling.

A prominent toxicity of androgen suppression in patients with prostate cancer (PCa) is loss of skeletal muscle. Exercise may induce tumor suppression through the endocrinal function of skeletal muscle; however, this is currently unknown. In this review, we summarize our work demonstrating the acute and chronic myokine response to exercise and the tumor-suppressive effect of circulatory milieu alteration in PCa patients.

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.