José A Bauermeister, Ryan C Tingler, Ken Ho, Rachel Scheckter, Tara McClure, Jontraye Davis, Jeanna Piper, Barbara A Friedland, Stacey Edick, Mei Song, Yuqing Jiao, Craig W Hendrix, Craig Hoesley
{"title":"PC-1005凝胶在三种不同体积水平下经直肠给药于HIV-1血清阴性成人的可接受性（MTN-037）。","authors":"José A Bauermeister, Ryan C Tingler, Ken Ho, Rachel Scheckter, Tara McClure, Jontraye Davis, Jeanna Piper, Barbara A Friedland, Stacey Edick, Mei Song, Yuqing Jiao, Craig W Hendrix, Craig Hoesley","doi":"10.1521/aeap.2022.34.4.257","DOIUrl":null,"url":null,"abstract":"<p><p>Multipurpose prevention technologies (MPT) have been increasingly researched for their dual-purpose preventative properties against HIV and other STIs. The acceptability of PC-1005, a topical MPT candidate, was explored among men and women participating in the MTN-037 Phase I trial at two U.S. sites (Pittsburgh, PA, and Birmingham, AL). We triangulated quantitative and qualitative assessments of the acceptability of three volumes (4 mL, 16 mL, 32 mL) of PC-1005 administered rectally (N = 12; 6 males, 6 females). Participants rated overall gel acceptability on a scale of 1-10, with a median of 7.17 (<i>SD</i> = 2.04) and had positive feelings about all three dose volumes, citing them to be very comfortable or comfortable (dose 1 = 91.7%; dose 2 = 91.7%; dose 3 = 83.3%). High acceptability of and comfort with all three dose volumes shows promise for PC-1005 as an MPT to prevent HIV and STIs, warranting future clinical development.</p>","PeriodicalId":47801,"journal":{"name":"Aids Education and Prevention","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924357/pdf/nihms-1871492.pdf","citationCount":"0","resultStr":"{\"title\":\"Acceptability of PC-1005 Gel Administered Rectally to HIV-1 Seronegative Adults at Three Different Volume Levels (MTN-037).\",\"authors\":\"José A Bauermeister, Ryan C Tingler, Ken Ho, Rachel Scheckter, Tara McClure, Jontraye Davis, Jeanna Piper, Barbara A Friedland, Stacey Edick, Mei Song, Yuqing Jiao, Craig W Hendrix, Craig Hoesley\",\"doi\":\"10.1521/aeap.2022.34.4.257\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Multipurpose prevention technologies (MPT) have been increasingly researched for their dual-purpose preventative properties against HIV and other STIs. The acceptability of PC-1005, a topical MPT candidate, was explored among men and women participating in the MTN-037 Phase I trial at two U.S. sites (Pittsburgh, PA, and Birmingham, AL). We triangulated quantitative and qualitative assessments of the acceptability of three volumes (4 mL, 16 mL, 32 mL) of PC-1005 administered rectally (N = 12; 6 males, 6 females). Participants rated overall gel acceptability on a scale of 1-10, with a median of 7.17 (<i>SD</i> = 2.04) and had positive feelings about all three dose volumes, citing them to be very comfortable or comfortable (dose 1 = 91.7%; dose 2 = 91.7%; dose 3 = 83.3%). High acceptability of and comfort with all three dose volumes shows promise for PC-1005 as an MPT to prevent HIV and STIs, warranting future clinical development.</p>\",\"PeriodicalId\":47801,\"journal\":{\"name\":\"Aids Education and Prevention\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2022-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924357/pdf/nihms-1871492.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aids Education and Prevention\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1521/aeap.2022.34.4.257\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"EDUCATION & EDUCATIONAL RESEARCH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aids Education and Prevention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1521/aeap.2022.34.4.257","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"EDUCATION & EDUCATIONAL RESEARCH","Score":null,"Total":0}
Acceptability of PC-1005 Gel Administered Rectally to HIV-1 Seronegative Adults at Three Different Volume Levels (MTN-037).
Multipurpose prevention technologies (MPT) have been increasingly researched for their dual-purpose preventative properties against HIV and other STIs. The acceptability of PC-1005, a topical MPT candidate, was explored among men and women participating in the MTN-037 Phase I trial at two U.S. sites (Pittsburgh, PA, and Birmingham, AL). We triangulated quantitative and qualitative assessments of the acceptability of three volumes (4 mL, 16 mL, 32 mL) of PC-1005 administered rectally (N = 12; 6 males, 6 females). Participants rated overall gel acceptability on a scale of 1-10, with a median of 7.17 (SD = 2.04) and had positive feelings about all three dose volumes, citing them to be very comfortable or comfortable (dose 1 = 91.7%; dose 2 = 91.7%; dose 3 = 83.3%). High acceptability of and comfort with all three dose volumes shows promise for PC-1005 as an MPT to prevent HIV and STIs, warranting future clinical development.
期刊介绍：
Presenting state-of-the-art research and information, AIDS Education and Prevention is a vital addition to the library collections of medical schools, hospitals, and other institutions and organizations with HIV/AIDS research programs. The journal integrates public health, psychosocial, sociocultural, and public policy perspectives on issues of key concern nationally and globally.
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