用于研究(纳米)疗法的泵送和无泵微物理系统。

IF 6.9 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Eun-Jin Lee, Zachary L Krassin, Hasan Erbil Abaci, Gretchen J Mahler, Mandy B Esch
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引用次数: 0

摘要

流体微物理系统(MPS)是一种微流体细胞培养装置,设计用于比传统的培养皿或孔板更好地模拟人体组织的生物化学和生物物理体内微环境。MPS生长的组织培养物可用于探索新药潜在的主要和次要毒性及其疗效。该系统还可用于评估环境纳米颗粒和纳米治疗药物的影响,包括它们的吸收率、生物分布、消除和毒性。无泵MPS是一组经常利用重力使细胞培养基通过其微流体网络再循环的MPS,提供了一些优势,但也带来了一些挑战。它们可以用接近生理量的血液替代物(即细胞培养基)进行操作,这些血液替代物可以根据设备配置以双向或单向流动模式再循环。在这里,我们讨论了泵送和无泵MPS的设计和使用方面的最新进展,重点是无泵装置在哪些方面可以有助于实现MPS在评估纳米材料方面的潜在未来作用。本文分类在:治疗方法和药物发现>纳米医学新兴技术毒理学和监管问题>纳米材料毒理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pumped and pumpless microphysiological systems to study (nano)therapeutics.

Pumped and pumpless microphysiological systems to study (nano)therapeutics.

Fluidic microphysiological systems (MPS) are microfluidic cell culture devices that are designed to mimic the biochemical and biophysical in vivo microenvironments of human tissues better than conventional petri dishes or well-plates. MPS-grown tissue cultures can be used for probing new drugs for their potential primary and secondary toxicities as well as their efficacy. The systems can also be used for assessing the effects of environmental nanoparticles and nanotheranostics, including their rate of uptake, biodistribution, elimination, and toxicity. Pumpless MPS are a group of MPS that often utilize gravity to recirculate cell culture medium through their microfluidic networks, providing some advantages, but also presenting some challenges. They can be operated with near-physiological amounts of blood surrogate (i.e., cell culture medium) that can recirculate in bidirectional or unidirectional flow patterns depending on the device configuration. Here we discuss recent advances in the design and use of both pumped and pumpless MPS with a focus on where pumpless devices can contribute to realizing the potential future role of MPS in evaluating nanomaterials. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials.

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来源期刊
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology NANOSCIENCE & NANOTECHNOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
16.60
自引率
2.30%
发文量
93
期刊介绍: Nanotechnology stands as one of the pivotal scientific domains of the twenty-first century, recognized universally for its transformative potential. Within the biomedical realm, nanotechnology finds crucial applications in nanobiotechnology and nanomedicine, highlighted as one of seven emerging research areas under the NIH Roadmap for Medical Research. The advancement of this field hinges upon collaborative efforts across diverse disciplines, including clinicians, biomedical engineers, materials scientists, applied physicists, and toxicologists. Recognizing the imperative for a high-caliber interdisciplinary review platform, WIREs Nanomedicine and Nanobiotechnology emerges to fulfill this critical need. Our topical coverage spans a wide spectrum, encompassing areas such as toxicology and regulatory issues, implantable materials and surgical technologies, diagnostic tools, nanotechnology approaches to biology, therapeutic approaches and drug discovery, and biology-inspired nanomaterials. Join us in exploring the frontiers of nanotechnology and its profound impact on biomedical research and healthcare.
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