纳米技术使放射性保护剂能够减少空间辐射诱导的反应性氧化物种。

IF 6.9 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Balaashwin Babu, Shreya Pawar, Agastya Mittal, Elayaraja Kolanthai, Craig J Neal, Melanie Coathup, Sudipta Seal
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引用次数: 1

摘要

随着现代空间技术最近的发射和运行,人们对太空探索的兴趣大幅增长。特别是,穿越近地轨道的可能性得到了持续的支持。然而,未来的深空旅行需要解决机组人员在持续、长期暴露于不利环境条件下的健康问题。在这些挑战中,辐射引起的健康问题是一个主要关切。微重力环境进一步增强了它们诱发慢性疾病的潜力。虽然对空间辐射的生理影响的调查仍在调查中,但对地球和微重力条件下的电离辐射模型条件的研究可以对相关过程提供必要的见解。辐射暴露期间大量形成高、持续的活性氧(ROS)进化,对太空旅行者的生理健康构成明显威胁,对各种细胞结构产生间接损伤,需要治疗。由于骨矿物质和局部造血的高无线电吸收截面,对骨骼系统组件的辐射防护对宇航员的健康至关重要。纳米技术可能对ROS和直接辐射损伤起到辐射保护剂和辐射减轻剂的作用。纳米颗粒组合物,如金、银、铂、碳基材料、二氧化硅、过渡金属二硫属化物和二氧化铈,都显示出作为可行的放射性保护剂的潜力,以减轻空间辐射效应。在几项研究中,纳米二氧化铈进一步显示出保护遗传物质免受氧化损伤的能力。随着空间辐射引发的健康问题研究的发展,这篇综述旨在为纳米材料的设计提供见解,以改善电离辐射暴露的病理影响。本文分类如下:治疗方法和药物发现>新兴技术生物学的纳米技术方法>生物学中的纳米系统生物学的纳米科技方法>纳米治疗方法和药品发现中的细胞>肿瘤疾病的纳米医学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nanotechnology enabled radioprotectants to reduce space radiation-induced reactive oxidative species.

Nanotechnology enabled radioprotectants to reduce space radiation-induced reactive oxidative species.

Interest in space exploration has seen substantial growth following recent launch and operation of modern space technologies. In particular, the possibility of travel beyond low earth orbit is seeing sustained support. However, future deep space travel requires addressing health concerns for crews under continuous, longer-term exposure to adverse environmental conditions. Among these challenges, radiation-induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro-gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio-absorption cross-section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon-based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation-induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

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来源期刊
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology NANOSCIENCE & NANOTECHNOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
16.60
自引率
2.30%
发文量
93
期刊介绍: Nanotechnology stands as one of the pivotal scientific domains of the twenty-first century, recognized universally for its transformative potential. Within the biomedical realm, nanotechnology finds crucial applications in nanobiotechnology and nanomedicine, highlighted as one of seven emerging research areas under the NIH Roadmap for Medical Research. The advancement of this field hinges upon collaborative efforts across diverse disciplines, including clinicians, biomedical engineers, materials scientists, applied physicists, and toxicologists. Recognizing the imperative for a high-caliber interdisciplinary review platform, WIREs Nanomedicine and Nanobiotechnology emerges to fulfill this critical need. Our topical coverage spans a wide spectrum, encompassing areas such as toxicology and regulatory issues, implantable materials and surgical technologies, diagnostic tools, nanotechnology approaches to biology, therapeutic approaches and drug discovery, and biology-inspired nanomaterials. Join us in exploring the frontiers of nanotechnology and its profound impact on biomedical research and healthcare.
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