Lu Ma, Yating Yan, Richard James Webb, Ying Li, Sanaz Mehrabani, Bao Xin, Xiaomin Sun, Youfa Wang, Mohsen Mazidi
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引用次数: 1
摘要
引言：心理压力与肠道微生物群组成之间的关系尚不完全清楚。这项研究调查了心理压力与肠道微生物群组成之间的关系，并考察了年龄、性别和种族对这种关系的潜在影响。方法：使用PubMed、Web of Science、PsycINFO和Embase数据库对截至2021年11月发表的研究进行系统的文献检索，这些研究考察了心理压力与肠道微生物群组成之间的关系。结果：在搜索过程中，确定了10790项研究，经过筛选，13项符合资格标准并被纳入。中位样本量为70，参与者的中位年龄为28.0岁。大多数纳入的研究都没有报告肠道微生物群组成的α和β多样性与心理压力之间的关系。一些研究报告称，Shannon指数、Chao 1、Simpson指数和加权UniFrac与心理压力呈负相关。在心理压力较高的参与者中，观察到门、科和属级别的几个分类群显著减少。在门的水平上，变形杆菌和疣菌的丰度与心理压力呈负相关。在家庭层面，不超过两项研究报告了同一微生物群与心理压力的关联。在属水平上，在两项以上的研究中发现了以下结果；心理压力与Lachnospira、Lachnosspiraceae、Phascolarctobacterium、Sutterella和Veillonella的丰度呈负相关，与Methanobrevibacter、Rhodococcus和Roseburia的丰度呈正相关。然而，由于纳入的研究有限，无法确定年龄、性别或种族的影响。结论：我们的研究结果提供了证据，表明心理压力与肠道微生物群丰度的变化有关。需要更大样本的纵向研究来确定心理压力和肠道微生物群之间的因果关系。
Psychological Stress and Gut Microbiota Composition: A Systematic Review of Human Studies.
Introduction: The associations between psychological stress and gut microbiota composition are not fully understood. This study investigated associations between psychological stress and gut microbiota composition and examined the potential modifying effects of age, sex, and ethnicity on such associations.
Methods: A systematic literature search was conducted using PubMed, Web of Science, PsycINFO, and Embase databases for studies published until November 2021 which examined associations between psychological stress and gut microbiota composition.
Results: During the search process, 10,790 studies were identified, and after screening, 13 met the eligibility criteria and were included. The median sample size was 70, and the median age of participants was 28.0 years. Most of the included studies did not report associations between measures of alpha- and beta diversity of the gut microbiota composition and psychological stress. A few studies reported that the Shannon index, Chao 1, Simpson index, and weighted UniFrac were negatively associated with psychological stress. Significant reductions in several taxa at the phyla-, family-, and genus-levels were observed in participants with higher psychological stress. At the phylum level, the abundance of Proteobacteria and Verrucomicrobia were negatively associated with psychological stress. At the family-level, no more than two studies reported associations of the same microbiota with psychological stress. At the genus level, the following results were found in more than two studies; psychological stress was negatively associated with the abundance of Lachnospira, Lachnospiraceae, Phascolarctobacterium, Sutterella, and Veillonella, and positively associated with the abundance of Methanobrevibacter, Rhodococcus, and Roseburia. However, it was not possible to determine the influence of age, sex, or ethnicity due to the limited studies included.
Conclusion: Our findings provide evidence that psychological stress is associated with changes in the abundance of the gut microbiota. Larger sample longitudinal studies are needed to determine the causal relationship between psychological stress and the gut microbiota.
期刊介绍：
The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.
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