用于脑机接口的导电聚合物基纳米结构材料。

IF 6.9 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Yasamin Ziai, Seyed Shahrooz Zargarian, Chiara Rinoldi, Paweł Nakielski, Antonella Sola, Massimiliano Lanzi, Yen Bach Truong, Filippo Pierini
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引用次数: 2

摘要

随着科学家们发现原始神经信号可以转化为生物电信息,用于实验和临床研究的脑机接口(BMI)经历了巨大的增长。为用于实时记录和数据数字化的生物电子设备开发合适的材料有三个重要的必要条件。所有材料都应采用生物相容性、导电性和类似于软脑组织的机械性能,以减少机械失配。在这篇综述中,讨论了无机纳米颗粒和固有导电聚合物,以赋予系统导电性,其中水凝胶等软材料可以提供可靠的机械性能和生物相容性基质。互穿水凝胶网络提供了更多的机械稳定性,并为将具有所需性能的聚合物结合到一个强大的网络中提供了一条途径。有前景的制造方法,如静电纺丝和增材制造,使科学家能够为每种应用定制设计,并达到系统的最大潜力。在不久的将来,人们希望制造负载有细胞的生物杂化导电聚合物基界面,为同时刺激和再生提供机会。开发多模态BMI,利用人工智能和机器学习设计先进材料是该领域未来的目标之一。这篇文章分类在:治疗方法和药物发现>神经疾病的纳米医学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Conducting polymer-based nanostructured materials for brain-machine interfaces.

Conducting polymer-based nanostructured materials for brain-machine interfaces.

As scientists discovered that raw neurological signals could translate into bioelectric information, brain-machine interfaces (BMI) for experimental and clinical studies have experienced massive growth. Developing suitable materials for bioelectronic devices to be used for real-time recording and data digitalizing has three important necessitates which should be covered. Biocompatibility, electrical conductivity, and having mechanical properties similar to soft brain tissue to decrease mechanical mismatch should be adopted for all materials. In this review, inorganic nanoparticles and intrinsically conducting polymers are discussed to impart electrical conductivity to systems, where soft materials such as hydrogels can offer reliable mechanical properties and a biocompatible substrate. Interpenetrating hydrogel networks offer more mechanical stability and provide a path for incorporating polymers with desired properties into one strong network. Promising fabrication methods, like electrospinning and additive manufacturing, allow scientists to customize designs for each application and reach the maximum potential for the system. In the near future, it is desired to fabricate biohybrid conducting polymer-based interfaces loaded with cells, giving the opportunity for simultaneous stimulation and regeneration. Developing multi-modal BMIs, Using artificial intelligence and machine learning to design advanced materials are among the future goals for this field. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.

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来源期刊
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology NANOSCIENCE & NANOTECHNOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
16.60
自引率
2.30%
发文量
93
期刊介绍: Nanotechnology stands as one of the pivotal scientific domains of the twenty-first century, recognized universally for its transformative potential. Within the biomedical realm, nanotechnology finds crucial applications in nanobiotechnology and nanomedicine, highlighted as one of seven emerging research areas under the NIH Roadmap for Medical Research. The advancement of this field hinges upon collaborative efforts across diverse disciplines, including clinicians, biomedical engineers, materials scientists, applied physicists, and toxicologists. Recognizing the imperative for a high-caliber interdisciplinary review platform, WIREs Nanomedicine and Nanobiotechnology emerges to fulfill this critical need. Our topical coverage spans a wide spectrum, encompassing areas such as toxicology and regulatory issues, implantable materials and surgical technologies, diagnostic tools, nanotechnology approaches to biology, therapeutic approaches and drug discovery, and biology-inspired nanomaterials. Join us in exploring the frontiers of nanotechnology and its profound impact on biomedical research and healthcare.
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