从上丘到基底神经节的通路

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Fernando Falkenburger Melleu, Newton Sabino Canteras
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引用次数: 0

摘要

本研究旨在回顾哺乳动物上丘(SC)的结构组织、连接上丘和基底神经节的假定通路及其在组织复杂行为输出中的作用。首先,我们回顾了上丘脑片状突起之间复杂的内在联系是如何构建周围环境的空间排列视觉多感觉地图的。此外,我们还总结了SC的感觉-运动输入,包括描述与行为控制相关的多感觉输入的整合。我们进一步研究了向脑干和脊髓的主要降序输出。作为这篇综述的核心部分,我们对视神经节和基底节之间可能存在的相互作用进行了深入分析。为此,我们探讨了丘脑的不同路径,包括通过侧后方、筋膜旁和喙椎丘脑内核的路径,丘脑信息可能通过这些路径到达纹状体。我们还研究了丘脑SC和丘脑下核之间的相互作用,这代表了构造调节基底节的另一条途径。此外,我们还讨论了来自SC的信息如何通过中脑构造和构造网状突起分别向黑质紧密区和室管膜区传递到基底节,从而影响流向背侧和腹侧纹状体的多巴胺能。我们强调了脊髓空洞和基底神经节之间的巨大相互作用,并提出了值得在未来研究中解决的几个缺失点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathways from the Superior Colliculus to the Basal Ganglia.

The present work aims to review the structural organization of the mammalian superior colliculus (SC), the putative pathways connecting the SC and the basal ganglia, and their role in organizing complex behavioral output. First, we review how the complex intrinsic connections between the SC's laminae projections allow for the construction of spatially aligned, visual-multisensory maps of the surrounding environment. Moreover, we present a summary of the sensory-motor inputs of the SC, including a description of the integration of multi-sensory inputs relevant to behavioral control. We further examine the major descending outputs toward the brainstem and spinal cord. As the central piece of this review, we provide a thorough analysis covering the putative interactions between the SC and the basal ganglia. To this end, we explore the diverse thalamic routes by which information from the SC may reach the striatum, including the pathways through the lateral posterior, parafascicular, and rostral intralaminar thalamic nuclei. We also examine the interactions between the SC and subthalamic nucleus, representing an additional pathway for the tectal modulation of the basal ganglia. Moreover, we discuss how information from the SC might also be relayed to the basal ganglia through midbrain tectonigral and tectotegmental projections directed at the substantia nigra compacta and ventrotegmental area, respectively, influencing the dopaminergic outflow to the dorsal and ventral striatum. We highlight the vast interplay between the SC and the basal ganglia and raise several missing points that warrant being addressed in future studies.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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