用于热疗和生物打印的磁响应透明质酸水凝胶:磁性、流变特性和生物相容性。

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL
APL Bioengineering Pub Date : 2023-09-07 eCollection Date: 2023-09-01 DOI:10.1063/5.0147181
L Vítková, N Kazantseva, L Musilová, P Smolka, K Valášková, K Kocourková, M Humeník, A Minařík, P Humpolíček, A Mráček, I Smolková
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引用次数: 0

摘要

磁响应软水凝胶可用于多种生物医学应用,如磁性热疗、药物输送、组织工程和神经调控。在这项研究中,这种水凝胶是由透明质酸(HA)填充 Al2O3 纳米粒子和多核磁粒子(MCPs)的二元体系制成的,后者是由超顺磁性氧化铁 FeOx NPs 聚簇而得。实验证明,二磁性 Al2O3 的存在有几个积极的作用:提高水凝胶的储存模量和在细胞培养介质中的长期稳定性;防止 MCPs 之间的磁性相互作用。在低振幅射频交变磁场下,HA 水凝胶每分钟可快速升温 0.3 ℃。此外,磁响应水凝胶还被成功用于包裹细胞和基于挤压的三维打印,细胞存活率达到 87±6%,从而提供了一种生物墨水。磁性 HA 水凝胶具有加热效率高、柔软、细胞相容性好和可三维打印等特点,是一种适合生物医学应用的材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Magneto-responsive hyaluronan hydrogel for hyperthermia and bioprinting: Magnetic, rheological properties and biocompatibility.

Magneto-responsive hyaluronan hydrogel for hyperthermia and bioprinting: Magnetic, rheological properties and biocompatibility.

Magneto-responsive hyaluronan hydrogel for hyperthermia and bioprinting: Magnetic, rheological properties and biocompatibility.

Magneto-responsive hyaluronan hydrogel for hyperthermia and bioprinting: Magnetic, rheological properties and biocompatibility.

Magneto-responsive soft hydrogels are used for a number of biomedical applications, e.g., magnetic hyperthermia, drug delivery, tissue engineering, and neuromodulation. In this work, this type of hydrogel has been fabricated from hyaluronan (HA) filled with a binary system of Al2O3 nanoparticles and multicore magnetic particles (MCPs), which were obtained by clustering of superparamagnetic iron oxide FeOx NPs. It was established that the presence of diamagnetic Al2O3 has several positive effects: it enhances the hydrogel storage modulus and long-term stability in the cell cultivation medium; prevents the magnetic interaction among the MCPs. The HA hydrogel provides rapid heating of 0.3 °C per min under exposure to low amplitude radio frequency alternating magnetic field. Furthermore, the magneto-responsive hydrogel was successfully used to encapsulate cells and extrusion-based 3D printing with 87±6% cell viability, thus providing a bio-ink. The combination of high heating efficiency, softness, cytocompatibility, and 3D printability of magnetic HA hydrogel leads to a material suitable for biomedical applications.

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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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