Iman M Ahmad, Lisa Bartenhagen, Kimberly Michael, Maher Y Abdalla
{"title":"职业暴露于电离和非电离辐射的成像专业人员的氧化还原失调。","authors":"Iman M Ahmad, Lisa Bartenhagen, Kimberly Michael, Maher Y Abdalla","doi":"10.1080/09553002.2023.2258194","DOIUrl":null,"url":null,"abstract":"<p><p><b>Purpose:</b> Imaging professionals are occupationally exposed to chronic ionizing radiation (IR) and non-ionizing radiation (NIR). This study aimed to investigate the influence of occupational radiation exposure on oxidative stress and antioxidant levels based on blood biomarkers in different hospital imaging professional groups.<b>Materials and methods:</b> The study groups included 66 imaging professionals occupationally exposed to IR (<i>n</i> = 58, 43 diagnostic radiography (G1), seven nuclear medicine (G2), eight radiation therapy (G3)), and NIR (<i>n</i> = 8, ultrasound imaging (G4)) and 60 non-exposed controls. Blood levels of superoxide (O<sub>2</sub><sup>•-</sup>) as an index of oxidative stress, and the antioxidant activities of superoxide dismutase (SOD), glutathione ratio (GSH/GSSG), and catalase (CAT) were measured.<b>Results:</b> The blood values of O<sub>2</sub><sup>•-</sup>, SOD, and CAT were significantly higher in imaging professionals occupationally exposed to radiation than in the control group (<i>p</i> < .05), while a significant decrease in the ratio of GSH/GSSG was observed (<i>p</i> < .05). The results from the NIR group were significantly higher compared to IR group.<b>Conclusions:</b> Based on these results, chronic exposure to radiation (IR and NIR) is associated with redox dysregulation that may result in damages to cellular biomolecules including lipids, proteins and DNA. Further studies are needed to determine the impact of redox dysregulation and the need for periodic examination among imaging professionals occupationally exposed to IR and NIR.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Redox dysregulation in imaging professionals occupationally exposed to ionizing and non-ionizing radiation.\",\"authors\":\"Iman M Ahmad, Lisa Bartenhagen, Kimberly Michael, Maher Y Abdalla\",\"doi\":\"10.1080/09553002.2023.2258194\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Purpose:</b> Imaging professionals are occupationally exposed to chronic ionizing radiation (IR) and non-ionizing radiation (NIR). This study aimed to investigate the influence of occupational radiation exposure on oxidative stress and antioxidant levels based on blood biomarkers in different hospital imaging professional groups.<b>Materials and methods:</b> The study groups included 66 imaging professionals occupationally exposed to IR (<i>n</i> = 58, 43 diagnostic radiography (G1), seven nuclear medicine (G2), eight radiation therapy (G3)), and NIR (<i>n</i> = 8, ultrasound imaging (G4)) and 60 non-exposed controls. Blood levels of superoxide (O<sub>2</sub><sup>•-</sup>) as an index of oxidative stress, and the antioxidant activities of superoxide dismutase (SOD), glutathione ratio (GSH/GSSG), and catalase (CAT) were measured.<b>Results:</b> The blood values of O<sub>2</sub><sup>•-</sup>, SOD, and CAT were significantly higher in imaging professionals occupationally exposed to radiation than in the control group (<i>p</i> < .05), while a significant decrease in the ratio of GSH/GSSG was observed (<i>p</i> < .05). The results from the NIR group were significantly higher compared to IR group.<b>Conclusions:</b> Based on these results, chronic exposure to radiation (IR and NIR) is associated with redox dysregulation that may result in damages to cellular biomolecules including lipids, proteins and DNA. Further studies are needed to determine the impact of redox dysregulation and the need for periodic examination among imaging professionals occupationally exposed to IR and NIR.</p>\",\"PeriodicalId\":14261,\"journal\":{\"name\":\"International Journal of Radiation Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/09553002.2023.2258194\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/9/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09553002.2023.2258194","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Redox dysregulation in imaging professionals occupationally exposed to ionizing and non-ionizing radiation.
Purpose: Imaging professionals are occupationally exposed to chronic ionizing radiation (IR) and non-ionizing radiation (NIR). This study aimed to investigate the influence of occupational radiation exposure on oxidative stress and antioxidant levels based on blood biomarkers in different hospital imaging professional groups.Materials and methods: The study groups included 66 imaging professionals occupationally exposed to IR (n = 58, 43 diagnostic radiography (G1), seven nuclear medicine (G2), eight radiation therapy (G3)), and NIR (n = 8, ultrasound imaging (G4)) and 60 non-exposed controls. Blood levels of superoxide (O2•-) as an index of oxidative stress, and the antioxidant activities of superoxide dismutase (SOD), glutathione ratio (GSH/GSSG), and catalase (CAT) were measured.Results: The blood values of O2•-, SOD, and CAT were significantly higher in imaging professionals occupationally exposed to radiation than in the control group (p < .05), while a significant decrease in the ratio of GSH/GSSG was observed (p < .05). The results from the NIR group were significantly higher compared to IR group.Conclusions: Based on these results, chronic exposure to radiation (IR and NIR) is associated with redox dysregulation that may result in damages to cellular biomolecules including lipids, proteins and DNA. Further studies are needed to determine the impact of redox dysregulation and the need for periodic examination among imaging professionals occupationally exposed to IR and NIR.
期刊介绍:
The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.